This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $339,038 to the University of Pittsburgh to study the prevalence and impact of frailty in older adults with polymyalgia rheumatica (PMR). The award period runs from Sep 15, 2024 to Aug 31, 2026. The key objectives are to: 1) Determine the association of frailty with glucocorticoid duration and prescription analgesic use in older adults with PMR, and 2) Examine the association of physical...
This federal Project Grant award of $3,343,725 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research by The Spaulding Rehabilitation Hospital Corporation investigating the opposing effects of skeletal muscle extracellular matrix aging and muscle activity on extracellular vesicle promotion of muscle regeneration. The research aims to mechanistically understand how age-related changes in the muscle extracellular matrix impact the molecular signatures of muscle-derived...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,631,690 to Beth Israel Deaconess Medical Center, Inc. (BIDMC) to develop a proteomic signature for predicting delirium risk and long-term cognitive decline in older cardiac surgery patients. The project aims to leverage plasma samples from the ongoing PANDORA clinical trial to derive and validate a delirium protein signature, as well as explore links between delirium, Alzheimer's disease, and...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $1,294,013 to Mayo Clinic to conduct a randomized clinical trial examining the impact of biological mechanisms of aging on exercise response variability in older adults. The project aims to define the heterogeneity in physical function and insulin sensitivity outcomes in response to a 6-month resistance training intervention, with a focus on investigating the...
This Project Grant award from the National Institute of Nursing Research (NINR), under CFDA 93.361 Nursing Research, provides $417,702 to Oregon Health & Science University (OHSU) to study the relationship between physical frailty, symptom monitoring and management behaviors, and outcomes in adults with heart failure. The research project aims to: 1) quantify the associations among physical frailty, symptom monitoring and management behaviors, and outcomes in heart failure patients; 2)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $835,056 to Trustees of Tufts College (Tufts University) to develop a multi-modal system of wearable biosensors and associated machine learning algorithms for the continuous monitoring of mobility and cognitive function in an aging population. The key products and services to be delivered under this award include: 1) a system of flexible, breathable, and inconspicuous eutectogel sensor patches...
This Project Grant award of $126,099.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research conducted by the University of California, San Francisco (UCSF) to investigate molecular phenotypes of frailty in lung transplantation. The principal investigator, an Associate Professor and lung transplant pulmonologist, will leverage existing research programs and collaborations to examine the heterogeneous pathobiology of pre- and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,545,208 to the Florida Institute for Human & Machine Cognition (IHMC) to conduct a 5-year research study on exercise response heterogeneity in older adults. The project aims to understand the mechanisms driving variability in older adults' responses to combined endurance and resistance training, with a focus on factors related to aging hallmarks like proteostasis, mitochondrial...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) aims to provide an integrated view of the complex pathophysiology of knee osteoarthritis (KOA) and mechanistically investigate how physiological exercise regulates molecular circuitry in cartilage and the surrounding knee joint in the setting of KOA. The award of $639,997 supports interdisciplinary research conducted by the Spaulding Rehabilitation Hospital Corporation to test the hypotheses that...
This $625,835 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to optimize aerobic fitness and functional response to exercise in older adults. The grant aims to test the efficacy of a combined high-intensity interval training (HIIT) and high-intensity resistance training (HIRT) approach to improve peak oxygen uptake (VO2peak) and physical function in patients eligible for cardiac rehabilitation, compared to standard...