Project Grant R03AG082996

Award Date 9/17/24
Completion Date 8/31/26
Dollars Obligated $676K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
New York, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a $636,957 study to investigate the relationship between prescription opioids, brain structure, and cognition in older adults with chronic pain. The single-center, double-blinded, placebo-controlled trial will enroll 200 participants with chronic pain due to osteoarthritis. The primary goal is to determine if opioid exposure is associated with changes in white matter integrity and global...
This $736,503 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a clinical trial to evaluate the effects of combining cognitive-behavioral therapy for insomnia (CBTI) and morning bright light treatment (MBLT) on chronic post-surgical pain (CPSP) and opioid use in older adults undergoing total knee arthroplasty surgery. The study aims to determine if this multimodal sleep-focused intervention can reduce the incidence of CPSP and opioid...
The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), has awarded a $299,553 Project Grant to Pilltrax Systems LLC to develop an enhanced medication management service for providers caring for African American and Latino older adults at risk of Alzheimer's disease and related dementias (ADRD). The proposed solution will comprise an electronic pill dispenser that sends medication adherence notifications, an adherence assessment tool, and a provider...
The National Institute on Aging (NIA) awarded a 2-year, $405,401 Project Grant under the Aging Research program (CFDA 93.866) to the University of Florida to conduct a multi-level analysis of factors influencing the response to medical marijuana treatment for chronic musculoskeletal pain in older adults. The key objectives are to: 1) Identify gene expression modules associated with changes in chronic pain severity following medical marijuana use, 2) Detect associations between changes in chronic...
This $4,950,026 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Icahn School of Medicine at Mount Sinai is investigating potential synergy between HIV infection and amyloid beta, a hallmark of Alzheimer's disease, in promoting memory impairment. Researchers will characterize enhanced HIV neuropathogenesis in familial and late-onset Alzheimer's disease mouse models...
This Project Grant award of $767,506 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) is funding research to leverage integrative modeling and AI-based tools to develop safer opioid medications. The goal is to elucidate the mechanistic basis of opioid efficacy and inform the design of novel, safer opioid therapeutics. The research team at the Icahn School of Medicine at Mount Sinai will use a Bayesian inference framework to...
This Project Grant award of $674,227, provided by the National Institute on Aging (NIA) under CFDA 93.866 Aging Research, will fund a study to evaluate the impact of the 340B Drug Pricing Program on Medicare Part D medication utilization, health outcomes, and disparities. The primary objectives are to: 1) Assess the impact of 340B program growth on Medicare Part D medication volumes and characteristics, overall and among disadvantaged subgroups; 2) Evaluate the impact of 340B eligibility on...
The National Institute on Aging (NIA) awarded a $656,000 Project Grant (CFDA 93.866 - Aging Research) to The Regents of the University of California, San Francisco (UCSF) to investigate the role of hyperalgesic priming in chronic pain experienced by the elderly. The research aims to: 1) establish that aged rats exhibit nociceptor plasticity (priming) and determine if it is associated with systemic inflammation, and 2) identify the mechanisms underlying priming in the elderly, including the...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research Federal Grant Program (CFDA 93.866) provides $1,394,250 to the Icahn School of Medicine at Mount Sinai to study the molecular mechanisms underlying pathological aging of the human brain and adipose tissue, as well as their inter-organ communication. The project aims to investigate the heterogeneity of human aging and identify the common pathological aging mechanisms shared between the brain (e.g., hippocampus,...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,073,250 to the University of California, San Diego (UCSD) to investigate age-related differences in opioid reward and addiction. The funded studies will use rat models to determine how the middle-adult developmental stage may influence sensitivity to prescription opioids, heroin, and fentanyl, compared to younger adulthood. The research aims...

The National Institute on Aging (NIA) awarded a $676,000 Project Grant under its Aging Research Federal Grant Program (CFDA 93.866) to the Icahn School of Medicine at Mount Sinai. The grant will fund research to study the unintended impact of the 2016 CDC opioid prescribing guidelines on disparities in opioid utilization among vulnerable subgroups of older adults, including those with Alzheimer's and related dementias, racial/ethnic minorities, and those experiencing socioeconomic deprivation. The research will analyze Medicare data from 2010-2020 to compare opioid use for opioid-responsive pain conditions like cancer and orthopedic trauma across these subgroups before and after the guideline implementation. The goal is to better understand if the guidelines had the unintended effect of limiting access to necessary opioid pain management in these vulnerable older adult populations.

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