The National Institute on Aging awarded a $151,000 Project Grant (CFDA 93.866 Aging Research) to Ohio University to investigate the role of the keratin 18 protein in mediating skeletal muscle adaptation to exercise and age-related muscle loss (sarcopenia). The overarching goal is to determine if the upregulation of keratin 18 facilitates skeletal muscle resilience and adaptation to physical stress, especially in older individuals susceptible to sarcopenia and frailty. The project will examine the effects of eccentric exercise on muscle strength, excitation-contraction coupling, and keratin 18 expression in young, adult, and old wild-type and keratin 18 knockout mice. Key objectives include elucidating the mechanisms by which keratin 18 promotes muscle adaptation to repeated bouts of physical stress and assessing the impact of age-related keratin 18 loss on the development of sarcopenia. The award period runs from September 30, 2023 to September 29, 2025.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $151.0k | 9/22/23 |