This Project Grant award of $152,400 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a study to characterize the associations between intraindividual cognitive variability (IICV), longitudinal changes in magnetic resonance imaging (MRI) measures related to Alzheimer's disease and Alzheimer's disease-related dementia (AD/ADRD), and diabetes among older American Indians. The study aims to: 1) examine whether IICV is associated with neurodegenerative-related MRI...
This $2,365,042 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to conduct research on the biological underpinnings of Alzheimer's disease and related dementias (ADRD). The research aims to better characterize the interplay between biological markers of neurodegeneration, vascular, nutritional, and inflammatory systems, and their interface with social and economic factors, by leveraging cross-national comparisons...
This Project Grant award of $715,539 from the National Institute on Aging (CFDA 93.866 - Aging Research) will develop a process to return Alzheimer's disease (AD) biomarker research results to a community-dwelling cohort of cognitively normal older adults. The study will evaluate whether these results can be safely and understandably sent directly to participants, which is critical as AD diagnostic blood tests and related treatments become more widely available. Specifically, the project will...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) federal grant program, provides $188,892 to the University of Washington to study microglial subpopulations that may contribute to resilience against Alzheimer's disease (AD). The goal is to address key gaps in understanding microglial subpopulation responses in resilient individuals, both in humans and mouse models, and to develop techniques to modify gene expression in specific...
The National Institute on Aging (NIA), through the Aging Research federal grant program (CFDA 93.866), awarded a $1,128,979 project grant to the University of Southern California (USC) to study the impact of ethnicity on the utility of plasma amyloid and tau biomarkers to predict Alzheimer's disease. The project aims to comprehensively measure phosphorylated tau (p-tau217) levels in plasma samples from the Health and Aging Brain Study-Health Disparities (HABS-HD) cohort, and investigate how...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $2,251,070 to the University of California Irvine through July 2025. The grant supports research to develop new statistical methodologies for analyzing Alzheimer's disease data from longitudinal cohort studies. Key deliverables include methods for assessing prediction precision for recurrent event survival data using time-dependent ROC and C-index...
This $322,286 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research to advance health equity in the use of novel treatments for Alzheimer's disease and related dementias (ADRD). The primary objectives are to: Conduct focus groups with diverse individuals affected by ADRD to understand their medication decision-making processes. Design and administer discrete choice experiments to learn how different treatment attributes are...
This federal Project Grant award for $372,690, provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program, is focused on discovering the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The primary goals are to: (1) develop new statistical methods for uncovering heterogeneous causal relationships between amyloid-beta, tau accumulation, and cognition across diverse AD patient subpopulations; (2) apply these novel methods to existing AD...
The National Institute on Aging (NIA) awarded a Project Grant (CFDA 93.866 - Aging Research) in the amount of $661,016 to the University of Southern California (USC) to develop a "Federated Deep Learning to Accelerate Alzheimer's Disease Research" project. The key products and services to be delivered include: Establishing an international "Federate AD" alliance to leverage innovative AI techniques and distributed computation to study Alzheimer's disease (AD) across large,...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $269,196 project grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of Arizona to develop a program focused on recruiting, training, and retaining Native American students in neuroscience education and research. The program aims to address the lack of Native American representation in STEM fields and health disparities in Native American communities...