Project Grant R01NS151302
- The National Institute of Neurological Disorders and Stroke awarded $588,794 to the University of South Florida on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating the functions of microglial laminin in blood-brain barrier repair and microglial activation following ischemic stroke. The research encompasses three aims: examining the function of microglial laminin in stroke...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded Tulane University $625,392 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of microglial activation and inflammatory cytokine secretion as mechanisms driving central nervous system consequences of intermittent pathogen exposure. The recipient will investigate viral...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pittsburgh $587,678 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to elucidate immune cell trafficking and biodegradation of bioscaffolds implanted in brain tissue using multi-color 19F magnetic resonance imaging. The research visualizes the spatio-temporal dynamics of peripheral immune cell accumulation and invasion into...
- The National Institute of Neurological Disorders and Stroke awarded $422,125 to the University of Miami on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct a randomized, waitlist-controlled mechanistic trial characterizing how auricular vagus nerve stimulation modulates HIV-associated peripheral neuropathy in aging adults. The study enrolls 70 adults aged 50 and older with chronic HIV-associated...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Miami $153,500 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to conduct research targeting the NLRP3 inflammasome as a therapeutic link between HIV-1 infection and ischemic stroke. The research employs both in vivo and in vitro approaches to test the hypothesis that HIV-1-induced activation of the NLRP3 inflammasome aggravates ischemic...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $551,557 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate nucleic acid sensing pathways in demyelinating disease. The funded research dissects the role of endosomal toll-like receptors (eTLRs) in neuroinflammation and demyelination, specifically examining how aberrant eTLR signaling in...
- The National Institute of Neurological Disorders and Stroke awarded Florida State University $448,943 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to engineer and bio-manufacture extracellular vesicles secreted by M2 microglia-like cells derived from human induced pluripotent stem cells for stroke therapy. The research aims to promote neural regeneration in ischemic stroke by developing extracellular vesicles that...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded $619,189 to Massachusetts Institute of Technology on August 19, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to establish a bioelectronics-integrated mesoscale organ-on-a-chip platform for neuromuscular disease modeling. MIT will develop a limb-on-a-chip platform that...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded The Medical University of South Carolina $100,228 on December 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research on complement-mediated mechanisms of injury and repair in germinal matrix hemorrhage, a leading neurological injury of prematurity....
- The National Institute of Neurological Disorders and Stroke awarded $242,250 to the University of Virginia on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award funds research into myeloid cell regulation of cerebrovascular tone and function, specifically investigating how microglia and perivascular macrophages maintain baseline vascular structure and blood flow in the brain and facilitate vascular responses...
The National Institute of Neurological Disorders and Stroke awarded the University of Miami $581,794 on September 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into inflammasome activation and its role in the foreign body response triggered by chronically implanted microelectrodes in neural tissue. Microelectrode implants enable neuroprosthetic and neuromodulation technologies for patients with paralysis, psychiatric, and neuromotor disorders, but long-term stability and function are limited by chronic neuroinflammation at the electrode-tissue interface. The project investigates whether inflammasomes—multi-protein structures that initiate innate immune responses—drive pyroptotic cell death and chronic inflammation following microelectrode implantation, and whether modulating inflammasome activation can reduce inflammation while providing cellular protection. Research aims include determining the effects of inflammasome inhibition on foreign body response in neural implants and its impact on neuronal recordings. The University of Miami's Office of Research Administration – School of Medicine Division is the recipient. Performance occurs in Miami, Florida, with an ultimate completion date of June 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $581.8k | 9/3/26 |