Project Grant R01NS151264
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Iowa State University of Science and Technology $393,447 on July 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate disease-modifying effects of NRF2 activators in organophosphate nerve agent exposure models. The research tests whether combining neuroprotectants with current medical countermeasures will prevent long-term neurotoxicity and epilepsy development...
- The National Institutes of Health Office of the Director awarded Texas A&M University System Health Science Center $423,500 on June 12, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate 2-deoxyglucose therapy as an adjunct neuroprotectant to midazolam in mitigating long-term neurological effects from acute organophosphate pesticide and nerve agent exposure. The project seeks to identify glycolysis inhibition as a novel countermeasure by testing the...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded University of California, Davis $442,750 on April 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant R21NS142879). UC Davis will conduct high-throughput screening of novel inverted terminal repeat (ITR) domains in the mouse brain to optimize adeno-associated viral...
- The National Institutes of Health Office of the Director awarded $471,000 to Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, on August 15, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to support Project Grant R01NS144283 investigating astrocyte-based mechanisms of organophosphate poisoning. The award funds research examining how astrocytes—glial cells abundant in the brain—contribute to injury from acute organophosphate exposure,...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, Davis $622,252 on August 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to fund research into the functional biology of alternative promoters in the cerebral cortex. The research investigates how alternative promoters—multiple transcription start sites present in over half of human genes—regulate isoform selection and drive...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, Davis $489,732 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on the regulation of extrasynaptic AMPA receptors by transmembrane auxiliary proteins, with focus on understanding how reserve pools of extrasynaptic receptors maintain synaptic plasticity mechanisms underlying learning and memory. The...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $395,009 to the University of California, Davis on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The two-year project, extending through July 31, 2027, supports foundational research to develop antisense oligonucleotide (ASO) therapy for ADNP syndrome (Helsmoortel-van der Aa syndrome), a severe...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded the University of California, Davis $3.432 million on July 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the relationship between SARS-CoV-2 infection and tau pathology in neurodegeneration. UC Davis will conduct research using two complementary rhesus macaque models to evaluate whether SARS-CoV-2...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $442,750 Project Grant to the University of California, Davis on August 6, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award supports a two-year research initiative (completion date July 31, 2027) investigating soluble epoxide hydrolase (SEH) inhibition as a neuroprotective intervention for perinatal brain...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, San Diego $129,643 on January 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to discover and characterize novel general anesthetics targeting GABAA receptors. The funded research aims to identify GABAA receptor modulators with improved safety profiles compared to existing intravenous anesthetics such as propofol and etomidate,...
The National Institutes of Health Office of the Director awarded University of California, Davis $468,559 on August 20, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate JAK/STAT signaling as a therapeutic target to mitigate long-term neurological effects of acute organophosphate intoxication. The research tests whether pharmacological inhibition of STAT3 can reduce spontaneous recurrent seizures and cognitive decline following organophosphate exposure. Using a rat model of acute diisopropylfluorophosphate (DFP) intoxication, the work will define the spatiotemporal dynamics of STAT3 activation and evaluate whether the FDA-approved JAK1/2 inhibitor ruxolitinib, administered as an adjunct to standard care, mitigates long-term adverse neurological consequences including neurodegeneration and memory loss. Current medical countermeasures inadequately protect against these deficits in organophosphate exposure survivors. The period of performance runs through July 31, 2029. Work is performed in Sacramento, California. The assistance type is a Project Grant, classified under Trans-NIH Research Support, which funds multiple offices within the NIH Office of the Director and is subject to standard NIH peer review for scientific and technical merit and program relevance.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $468.6k | 8/20/26 |