Project Grant R01NS146486
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded University of California, Davis $442,750 on April 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant R21NS142879). UC Davis will conduct high-throughput screening of novel inverted terminal repeat (ITR) domains in the mouse brain to optimize adeno-associated viral...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, Davis $126,845 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to establish the UC Davis Neuroscience Education and Undergraduate Research Opportunities (NEURO) Program. The NEURO Program will recruit six upper-division undergraduate students per year to participate in a one-year research-intensive experience combining...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $395,009 to the University of California, Davis on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The two-year project, extending through July 31, 2027, supports foundational research to develop antisense oligonucleotide (ASO) therapy for ADNP syndrome (Helsmoortel-van der Aa syndrome), a severe...
- The National Institute of Neurological Disorders and Stroke awarded The Scripps Research Institute $710,155 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate post-transcriptional mechanisms of cortical inhibitory interneuron development. The research focuses on identifying how microRNA-mediated regulation controls interneuron migration and specification during development. The work employs engineered...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, Davis $489,732 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on the regulation of extrasynaptic AMPA receptors by transmembrane auxiliary proteins, with focus on understanding how reserve pools of extrasynaptic receptors maintain synaptic plasticity mechanisms underlying learning and memory. The...
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $2,656,684 on February 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to discover and validate gene therapy and biologic delivery vectors for central nervous system diseases using physiologically maintained deceased human cadavers as a discovery platform. The award funds development of an...
- The National Institute of Neurological Disorders and Stroke awarded The Leland Stanford Junior University $522,632 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of pseudouridine synthase PUS7 in neurodevelopment. The recipient will use two-dimensional and three-dimensional in vitro neuronal differentiation systems, primary tissues and cells, cutting-edge sequencing tools for RNA modification...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, Los Angeles $639,095 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on temporal control of neurogenesis termination in developing mammalian brains. The research investigates the molecular mechanisms by which neural stem cells, or radial glia, cease generating neurons shortly after birth—a process...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services, awarded $429,000 to The Regents of the University of Colorado, doing business as University of Colorado-Denver, on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Program Grant R21NS151067). The award funds research on transcriptional and epigenetic regulation of neural progenitor fates during...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $126,900 on March 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to exploit RNA biogenesis, specifically alternative splicing programs, to accelerate maturation of human neurons in vitro and to develop models of age-related tauopathies. The research addresses a fundamental...
The National Institute of Neurological Disorders and Stroke awarded the University of California, Davis $622,252 on August 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to fund research into the functional biology of alternative promoters in the cerebral cortex. The research investigates how alternative promoters—multiple transcription start sites present in over half of human genes—regulate isoform selection and drive diversity in gene expression patterns, particularly in the brain. The project examines cell-type and stage-specific promoter activity, transcriptional regulatory mechanisms, and functional relevance of alternative promoters in the cerebral cortex, with emphasis on neurodevelopmental and neurological disorders where alternative isoforms feature prominently. The work employs single-cell and long-read RNA sequencing technologies to characterize promoter accessibility, gene expression, and isoform use in healthy and diseased brain tissue. Performance occurs in Davis, California. The award period runs from August 20, 2026, through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $622.3k | 8/20/26 |