Project Grant R01NS150462
- The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $150,512 on August 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into controlling epilepsy symptoms through precisely timed inhibition and circuit editing, focused on temporal lobe epilepsy and cognitive impairments associated with seizure disorders. The research employs closed-loop...
- The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $667,738 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of dentate spikes in cognition and epilepsy. The research uses in vivo electrophysiology with silicon probes to characterize neural activity synchronization across the medial entorhinal cortex and hippocampus during type 2 dentate...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $491,163 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award, effective August 1, 2025, through July 31, 2027, supports research investigating the mechano-electrical regulation of neurogenesis during brain development. The research explores how inner...
- The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $670,266 on January 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to map the epigenomic and spatial transcriptomic landscape in Parkinson's disease and Alzheimer's disease. The project characterizes shared and distinct transcriptional changes between Parkinson's disease, Alzheimer's disease, and Alzheimer's...
- The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $1,967,309 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to dissect the role of small non-coding RNAs in microglia-driven neuroinflammation in Alzheimer's disease. The funded research will elucidate how small non-coding RNAs—including microRNA isoforms, transfer RNA-derived fragments, ribosomal RNA-derived...
- The National Institute of Neurological Disorders and Stroke awarded New York University $247,994 on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on ictal onset patterns and responsive neurostimulation outcomes in drug-resistant epilepsy. Dr. Andrew Michalak, an assistant professor of neurology at New York University Grossman School of Medicine, leads the project. The research explores the basic...
- The National Institute of Neurological Disorders and Stroke awarded $574,660 to Icahn School of Medicine at Mount Sinai on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate neutrophil extracellular trap mitigation in ischemic stroke outcomes. The research addresses vascular contributions to cognitive impairment and dementia following acute ischemic stroke by examining how neutrophils form extracellular...
- The National Institute of Neurological Disorders and Stroke awarded Rutgers The State University of New Jersey $607,954 on July 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to identify and validate the chokepoints of epileptogenic networks in mesial temporal lobe epilepsy—specific brain regions where multiple ictogenic pathways converge—to improve surgical outcomes for patients with drug-resistant...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Emory University $420,142 on May 4, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to explore the contribution of extracellular vesicles to epileptogenesis in temporal lobe epilepsy and Dravet syndrome. The research examines how extracellular vesicles—small membranous particles...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $462,000 on August 14, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop a novel spatial transcriptomics platform and investigate RNA-binding protein function in human neurons as it relates to schizophrenia risk. The award funds two primary aims. The first develops a spatial RNA-protein interactome MERFISH (SPRIM) platform to visualize endogenous RNA-protein interactions at...
The National Institute of Neurological Disorders and Stroke, an operating division of the National Institutes of Health under the Department of Health and Human Services, awarded $646,706 to Icahn School of Medicine at Mount Sinai on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to develop and validate magnetic resonance elastography and arterial spin labeling as novel complementary imaging markers for identifying the epileptogenic zone in drug-resistant epilepsy patients. The project aims to evaluate the diagnostic accuracy of these brain MRI techniques in localizing seizure foci and to investigate the coupling between tissue biomechanics and perfusion in drug-resistant epilepsy versus healthy individuals. The underlying hypothesis posits that glial activation in epilepsy alters both tissue stiffness and blood perfusion properties in ways measurable through non-invasive imaging, with these alterations reflecting reactive astrogliosis and associated vascular remodeling. Work is performed at Icahn School of Medicine at Mount Sinai in New York, New York. The period of performance runs from August 15, 2026, through July 31, 2031. This is a Project Grant, the standard NIH research award mechanism supporting investigator-initiated biomedical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $646.7k | 8/14/26 |