Project Grant R01NS150276
- The National Institute of General Medical Sciences awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $431,750 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate gasdermin-D-mediated mitochondrial transfer as a mechanism of inflammatory response amplification. The research examines whether horizontal transfer of damaged mitochondria between cells propagates pro-inflammatory signaling in recipient cells,...
- This $2,069,215 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by Case Western Reserve University to investigate the role of the beta-arrestin2-LMBRD2 pathway in the transmission and toxicity of pathological alpha-synuclein, which is a defining hallmark of Lewy body diseases such as Parkinson's disease and dementia with Lewy bodies. The research will utilize cellular and animal models to study the mechanisms by which beta-arrestin2...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $452,375 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate astrocyte-mediated tonic inhibition in a mouse model of Lewy body dementia. The research explores mechanisms linking GBA1 gene mutations to Lewy body dementia pathology by using an astrocyte-specific GBA1 conditional knockout mouse model crossed with a THY1-ASYN transgenic model that overexpresses human...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $544,568 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University on February 11, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the pathogenesis of permanent neurological disability in multiple sclerosis. The research identifies cellular...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $634,938 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate RNA editing dysregulation in dementia with Lewy bodies and Parkinson's disease. The research addresses how proteostasis failure in these neurodegenerative conditions leads to accumulation of nuclear inclusions containing RNA binding proteins NONO and SFPQ,...
- The National Institute of Neurological Disorders and Stroke awarded $235,500 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support single-cell morphological dissection of brain endothelial cells. The award funds research investigating cerebrovascular integrity at the single-cell level, with focus on endothelial cell...
- The National Institute of Neurological Disorders and Stroke awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $877,250 on May 6, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate aberrant M6A methylation correlating with hippocampal pathology in multiple sclerosis. The research examines how demyelination alters N6-methyladenosine (M6A) methylation patterns in gene transcripts...
- Federal Grant Award Summary Cleveland Clinic Lerner College of Medicine of Case Western Reserve University received a $4.92 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to validate novel biomarkers for cognitive fluctuations in Alzheimer's disease and Dementia with Lewy Bodies. The research project, initiated September 1, 2025 and concluding July 31, 2029, will deliver a comprehensive multimodal characterization of cognitive...
- The National Institute of Neurological Disorders and Stroke awarded Brandeis University $436,864 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the molecular mechanisms by which hypoxia and genetic suppressors rescue mitochondrial Complex I function. The research combines C. elegans genetics, mitochondrial biochemistry, and cryogenic electron microscopy to define the structural basis of hypoxia...
- The National Institute of Neurological Disorders and Stroke awarded Brigham and Women's Hospital $492,250 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to identify the palmitoyltransferase for glucocerebrosidase trafficking receptor LIMP2 and restore GBA1 function in Parkinson disease and Lewy body dementia. The research investigates palmitoylation—modification of proteins by the fatty acid palmitate—as a...
The National Institute of Neurological Disorders and Stroke awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $432,711 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate mitochondrial gasdermin-D propagation of neuroinflammation and neurodegeneration in alpha-synucleinopathy. The research examines mechanisms by which alpha-synuclein aggregates trigger microglia-mediated innate immune responses—specifically the NLRP3 inflammasome and STING pathways—in Parkinson's disease, dementia with Lewy bodies, and alpha-synucleinopathy-associated Alzheimer's disease. The project focuses on cleaved gasdermin-D (cl-GSDMD) localization to mitochondria within microglia and its role in mitochondrial permeabilization, neuroinflammatory signaling, and neurodegeneration. Work includes in vitro and in vivo experimental tools and immunohistochemical analyses on postmortem dementia with Lewy bodies tissue. Performance occurs in Cleveland, Ohio, with a period of performance from September 1, 2026, through August 31, 2031. The assistance type is a project grant, a peer-reviewed extramural research award supporting basic and translational neuroscience research that advances fundamental knowledge of the brain and nervous system.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $432.7k | 8/25/26 |