Project Grant R35GM162199
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a Project Grant totaling $442,750 under the Biomedical Research and Research Training program (CFDA 93.859) on August 15, 2025, with a completion date of April 30, 2030. This five-year research initiative focuses on advancing fundamental understanding of how metabolites, specifically nitrate, shape microbiota ecology and...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Washington University $382,931 under the Biomedical Research and Research Training program (CFDA 93.859) to conduct fundamental research on mitochondrial AAA (ATPase-Associated with diverse cellular Activities) protease specificity and function. The five-year project, which commenced September 1, 2025, and concludes August 31, 2030, will employ an integrated multidisciplinary approach combining...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Massachusetts General Hospital a $453,750 Project Grant effective August 8, 2025, through June 30, 2030, under the Biomedical Research and Research Training program (CFDA 93.859). This research initiative investigates the metabolic control of membrane lysis and the molecular mechanisms governing regulated cell death pathways. The project delivers fundamental biomedical research examining how...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $840,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded May 1, 2025, with a completion date of March 31, 2030. The research program investigates the molecular mechanisms of stress-induced mitochondrial dysfunction, specifically focusing on how pathological conditions disrupt mitochondrial energy...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $440,000 through its Biomedical Research and Research Training program (CFDA 93.859) to the Sloan-Kettering Institute for Cancer Research, effective August 1, 2025, with completion targeted for May 31, 2030. This Project Grant supports fundamental research investigating the mechanisms of lipid droplet (LD) protein targeting—a critical area of cell biology with direct implications for...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of Maryland, Baltimore a $686,324 Project Grant effective September 1, 2025, through August 31, 2027, under the Biomedical Research and Research Training program (CFDA 93.859). This award funds mechanistic studies of E3 ubiquitin ligase function in peroxisomes and mitochondria, with the primary deliverable being fundamental research that advances understanding of the ubiquitin...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded UC San Diego a $249,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) for the period September 1, 2025 through August 31, 2028. This award supports fundamental research to advance understanding of how biophysical cues shape macrophage and T-cell functions in the context of inflammation and cancer. The research deliverables include the development and...
- Federal Grant Award Summary Boston University Medical Campus received a $439,148 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on March 13, 2026, with a completion date of January 31, 2031. This five-year research initiative aims to elucidate the fundamental mechanisms of mitochondrial deoxyribonucleic acid (DNA) packaging and gene expression to advance understanding of metabolic...
- Federal Project Grant Award Summary Case Western Reserve University (CWRU) was awarded a Project Grant of $402,500 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, with a completion date of July 31, 2030. This NIGMS Maximizing Investigators' Research Award (MIRA) supports an early-stage investigator conducting research on heme-based immune dysregulation in critical illness. The grant will...
- Federal Grant Award Summary Cleveland Clinic Lerner College of Medicine of Case Western Reserve University received a $639,621 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 15, 2025 through March 31, 2029. The research project investigates mitochondrial involvement in transcellular cross-talk between cardiomyocytes and fibroblasts, with particular focus on understanding how...
The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant of $431,750 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). This five-year research project, scheduled for completion on January 31, 2031, funds investigator-initiated biomedical research designed to advance understanding of biological processes and establish foundations for advances in disease diagnosis, treatment, and prevention. The research focuses on the role of gasdermin-D (GSDMD) in mitochondrial-mediated inflammatory responses, specifically examining how horizontal mitochondrial transfer may propagate pro-inflammatory signaling through recipient cells. The project investigates the mechanisms by which the NLRP3 inflammasome and STING complex pathways respond to dysfunctional mitochondria, with emphasis on how cleaved GSDMD translocates to mitochondria to amplify reactive oxygen species release and inflammasome activation. The award supports basic research conducted at the institution's Cleveland, Ohio facilities, contributing to the broader scientific understanding of innate immune signaling pathways relevant to inflammation, aging, and disease processes.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.8k | 3/24/26 |