Project Grant R01NS149478
- The National Institutes of Health (NIH) Office of the Director awarded a $1,345,424 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Regents of the University of Michigan. The grant, effective September 10, 2024 through September 9, 2027, aims to develop a novel genetically encoded "protein ticker tape" system that enables long-term, brain-wide recording of single-cell physiology in live mice without external interfacing. The technology will leverage...
- This Project Grant award of $431,750 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports the development of an innovative PET molecular neuroimaging technique to non-invasively image whole-brain neurocircuitry in awake mammals. The technique utilizes a brain-penetrant PET imaging probe and a neuronal activity-dependent...
- The National Institutes of Health (NIH) awarded a $1,385,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Allen Institute, a non-profit research organization, to develop novel techniques for measuring the input-output operations of individual neurons in the mouse cortex. The project aims to overcome challenges in understanding how neurons in the mammalian brain transform their synaptic inputs into outputs, which is critical for designing effective brain-machine...
- The University of Michigan received a $1,714,839 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The objective of this proof-of-concept study is to develop bispecific antibodies (Babs) fused to IL-2, referred to as IL-2 immunocytokines, that can be delivered non-invasively via intravenous administration, efficiently cross the...
- The National Institutes of Health's National Institute of Neurological Disorders and Stroke awarded a $3,045,502 Project Grant to the Regents of the University of Michigan on August 18, 2022 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The grant funds the development of optical neural motes to enable high-density neural recording through intact dura in nonhuman primates. Specifically, the University of Michigan will design...
- This federal Project Grant award of $460,500 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) is aimed at developing novel bioprinting methodologies for the production of human stem cell-based organoids. The key objectives are to: 1) Create a customized bioink formulation using proteins, polysaccharides, and functionalized nanoparticles to foster the...
- The federal Project Grant award of $621,500 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The goal of the project is to develop new methods for combined molecular and ultrastructural imaging of neural cells and tissues using advanced nanoprobes and cathodoluminescent dyes. Specifically, the award will fund the development of (1) detergent-free...
- The National Institutes of Health (NIH) Office of the Director awarded a $1,271,280 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Allen Institute in Seattle, WA. The award, spanning September 2024 to September 2027, aims to develop two "exa-scale" (extremely high-throughput) tissue readout methods to transform the study of the brain. The first method will enable highly multiplexed molecular mapping of individual proteins across entire brains at the...
- The National Institutes of Health (NIH) awarded a $384,999 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to The Leland Stanford Junior University (Stanford University) to develop "smart" gene therapies that utilize injury-specific regulatory elements to enable dynamic, real-time adaptation of therapeutic gene expression to disease conditions. The key objectives are to: 1) Harness endoplasmic reticulum (ER) stress-responsive promoters to achieve...
- This $556,525 Project Grant was awarded on June 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant will fund the development, testing, and dissemination of micro-LED optoelectrode platforms for monitoring and perturbing targeted neurons in multiple local brain circuits. These platforms will provide a new tool for analyzing the dynamic...
The U.S. Department of Health and Human Services, National Institutes of Health (NIH) awarded a $878,991 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences. The award period is from September 10, 2025 to August 31, 2030. The project aims to develop "I/O tags" - genetically encoded proteins that can achieve targeted trans-neuronal delivery to selectively control and report on signal transduction, neuronal activity, and gene expression across specific synapse classes in the mammalian brain, without the need for replicative neurotropic viruses. This transformative technology would enable robust experimental control and therapeutic treatment of complex neuronal circuits, addressing a critical gap in the current state-of-the-art neuroscience tools. The research partnership has significant expertise in advanced medical research, healthcare innovation, and translating scientific discoveries into clinical applications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $879.0k | 9/10/25 |