Federal Grant Award Summary

The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Johns Hopkins University a Project Grant totaling $388,646 (awarded June 16, 2026; completion date May 31, 2031) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research project investigates the molecular mechanisms of delta-2 receptor (GluD2) dysfunction in neurological diseases, specifically examining how disease-associated mutations in the human GluD2 receptor affect cerebellar function and contribute to disorders including cerebellar ataxia, autism spectrum disorder, and schizophrenia. The research will employ an integrated biophysical approach utilizing precision electrophysiology and structural biology to characterize how mutations in the amino terminal domain, ligand binding domain, and transmembrane domain alter receptor function and architecture at the molecular level.

This basic research initiative addresses a critical gap in understanding GluD2's pathophysiology and therapeutic potential, building on recent findings from the investigator's laboratory that clarified GluD2 as a bona fide ligand-gated ion channel. The work will establish a foundation for developing pharmacologic strategies targeting this receptor and may ultimately inform therapeutic approaches for neurological and neurodevelopmental disorders associated with GluD2 dysregulation. Research performance will be conducted at Johns Hopkins University's Baltimore, Maryland facility.