Project Grant R01NS146939
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $438,625 Project Grant to the University of California, San Diego on August 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research initiative, extending through July 31, 2027, investigates a novel neuroprotective mechanism against ischemic brain injury by characterizing "actinification"—a pro-survival...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Wisconsin–Madison a $629,031 Project Grant effective June 1, 2025, through February 28, 2030, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative will develop and validate Optical Cell State Imaging (OCSI), a label-free, live-cell classification technology designed to distinguish...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $520,025 to the University of Connecticut Health Center on July 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop next-generation RNA inhibitors for ischemic stroke therapy. The research focuses on developing peptide nucleic acid (PNA) analogs, particularly gamma (γ) PNA-based microRNA-141-3p (mir-141-3p)...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Alabama at Birmingham $540,236 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program on September 1, 2025, for a five-year project period concluding August 31, 2030. This project grant funds research to develop and evaluate small molecule inhibitors targeting the RNA regulator HUR (human antigen R) as a therapeutic...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Wisconsin-Madison a $414,305 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program for the period August 1, 2025 through July 31, 2027. This award supports research investigating single-cell transcriptomics to identify cellular mechanisms underlying epileptogenesis—the progressive process by which seizure...
- Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of California, Davis a $457,714 Project Grant on July 15, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award funds fundamental neuroscience research investigating post-transcriptional regulatory mechanisms governing cortical cell fate specification in the developing brain. The research will employ advanced molecular...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Leland Stanford Junior University a Project Grant of $125,685 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 9, 2025, with a completion date of July 31, 2027. This research initiative focuses on developing bioactive material interventions to address post-stroke dementia, a significant health concern...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $626,034 Project Grant to The Regents of the University of California, San Francisco on August 6, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative, scheduled for completion by June 30, 2030, aims to identify cortical and brainstem regions that contribute to preserved hand function following...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $521,839 to the University of California, San Diego on August 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This five-year project grant, scheduled for completion by July 31, 2030, supports fundamental research investigating the mechanisms of pathogenic microglial populations in central nervous system (CNS)...
- Federal Grant Award Summary The University of Michigan received a $633,146 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 4, 2025, with completion targeted for July 31, 2030. The project addresses vascular cognitive impairment and dementia (VCID) following stroke by investigating modifiable risk factors and prevention...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Wisconsin-Madison a $494,240 Project Grant on February 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The research project, extending through January 31, 2031, investigates microRNA (miRNA) degradation mechanisms in post-stroke brain tissue. The principal research deliverable involves elucidating the role of target-directed miRNA degradation (TDMD) pathways in regulating miRNA stability following ischemic stroke, with specific focus on the relationship between the long non-coding RNA CYRANO and miRNA-7, a microRNA significantly downregulated post-stroke that contributes to alpha-synuclein induction and brain injury exacerbation. The research aims to produce findings that advance understanding of post-stroke molecular pathology and identify potential therapeutic intervention targets through gene regulation mechanisms. Through peer-reviewed, merit-based investigation, the project will generate scientific knowledge regarding how target RNAs induce miRNA degradation in ischemic brain conditions, complementing the NINDS mission to reduce the burden of neurological disease through fundamental and translational neuroscience research.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $494.2k | 2/16/26 |