Project Grant R01NS141123
- The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $125,685 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Leland Stanford Junior University (Stanford University). The funding will support the development of an injectable hydrogel with an integrated urokinase plasminogen activator (uPA) motif and plasmid DNA (pDNA) platelet-derived growth factor B (PDGFB)-lipoplexes to be loaded into the...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of the CCL2/CCR2 signaling pathway in modulating HIV-associated ischemic stroke severity and recovery. The $422,125 award, effective from September 18, 2024 to August 31, 2026, will be conducted by the University of Miami. The research aims to...
- This $520,025 Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop new peptide nucleic acid (PNA) inhibitors targeting the miR-141-3p microRNA for potential stroke therapy. The research focuses on synthesizing and characterizing more potent gamma-PNA (GPNA) analogs of the miR-141-3p inhibitor, with the primary goal of...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...
- This federal Project Grant award, valued at $492,749.00 and awarded by the National Institute of Neurological Disorders and Stroke (NINDS), supports the development of a novel non-invasive magnetic resonance imaging (MRI) technique called ratiometric dual contrast (RDUAL) pH-weighted MRI. The goal is to create an imaging tool that can accurately map the ischemic penumbra (tissue at risk of infarction) and evaluate the risk of reperfusion injury in acute ischemic stroke patients. This research,...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $671,988 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Winifred Masterson Burke Medical Research Institute, Inc. The project focuses on understanding the cross-talk between two cell death pathways, sarmoptosis and ferroptosis, in the context of intracerebral hemorrhage (ICH), a type of stroke. The research aims to explore how the accumulation...
- This Project Grant award of $192,500 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to define the contribution of endothelial cell sphingolipid metabolism to outcomes of acute ischemic stroke in mice. The award, effective December 1, 2024, will enable the University of Utah to leverage innovative murine models and novel ceramide biosynthesis...
- This Project Grant award of $438,625.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at the University of California, San Diego (UCSD) to characterize and augment a novel pro-survival mechanism in neurons during ischemic brain injury. The research aims to investigate the role of the protein INF2 in driving "actinification", a...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $541,109 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Washington. The 5-year grant, beginning January 1, 2025, will fund research to quantify myelin loss and recovery in ischemic stroke patients using a novel magnetic resonance imaging (MRI) technique called single-point macromolecular proton fraction (MPF) mapping. The...
- This federal Project Grant award of $664,458, provided by the National Institute of Neurological Disorders and Stroke (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders), supports research to develop a novel non-invasive optical imaging technique for the prehospital detection of large vessel occlusion (LVO) in acute stroke patients. The University of Pennsylvania, the grant recipient, is validating this optical cerebral hemodynamic monitoring approach...
This $540,236 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is funding research to target the RNA regulator HuR in order to suppress inflammation and promote neuroprotection in acute ischemic stroke. The University of Alabama at Birmingham is the primary awardee and will conduct preclinical studies to investigate the efficacy of a novel class of small molecule HuR inhibitors in reducing tissue injury and inflammation following ischemic stroke. The project aims to advance the understanding of neuroinflammatory pathways and develop potential new treatments to address the significant gap in neuroprotective therapies for ischemic stroke patients. The award period runs from September 1, 2025 to August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $540.2k | 7/28/25 |