Project Grant R01NS146844
- The National Institute of Neurological Disorders and Stroke awarded Yale University $583,646 on March 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate cilia disassembly and dysfunction in malformations of cortical development. Malformations of cortical development are neurological disorders characterized by altered organization and function of cortical neurons, often resulting in intractable epileptic...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded $120,582 to President and Fellows of Harvard College (operating as Harvard Medical School) on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining the functional specializations of cerebellar interneuron subtypes and their roles...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $478,732 to Seattle Children's Hospital to characterize the cellular and molecular features of human cerebellar progenitor zones. The research leverages expertise in human cerebellar development and access to fetal tissue to conduct in vitro assays, live imaging, and...
- The National Institute of Child Health and Human Development awarded Massachusetts General Hospital $681,793 on June 23, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to map the neuroarchitecture and connectivity development of the human cerebellum during the first postnatal year using cross-scale imaging techniques. The research addresses the gap between in vivo and ex vivo imaging of perinatal cerebellar injury, which occurs in up to 19% of...
- The National Institute of Neurological Disorders and Stroke awarded Duke University $478,336 on August 15, 2026, to investigate cortico-cerebellar interactions underlying goal-directed actions under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The research will examine how neural circuits in the brain, specifically interactions between the anterior lateral motor cortex and the cerebellum, give rise to goal-directed movement planning...
- The National Institute of Neurological Disorders and Stroke awarded The University of Iowa $540,503 on May 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct basic neuroscience research on cerebellar interactions with forebrain structures during associative learning. The research systematically analyzes how the cerebellum interacts with the anterior cingulate cortex and hippocampus during trace conditioning in rats....
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded ST Jude Children's Research Hospital Inc. $690,296 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate nuclear condensation and chromatin reorganization during cerebellar granule neuron differentiation. The research employs three integrated approaches: innovative CMAP epigenetic imaging probes to...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Yale University $667,613 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining ferroptosis—iron-induced programmed cell death—in erythrocytes within intracerebral hemorrhage hematomas. The project investigates how heme induces...
- The National Institute of Neurological Disorders and Stroke awarded Yale University $513,602 on June 19, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to define the role of non-clustered protocadherins in forebrain circuit assembly and complex behavioral execution. The research explores how non-clustered protocadherins, including protocadherin-17, establish reciprocal connectivity patterns between forebrain regions—the cerebral...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $509,949 on August 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support basic research elucidating mechanisms of chromosomal organization in control of neuronal connectivity in the brain. The funded research investigates mega-enhancer bodies (ME bodies) that compartmentalize neuronal long genes encoding synaptic proteins within...
The National Institute of Neurological Disorders and Stroke, an operating division of the National Institutes of Health under the Department of Health and Human Services, awarded $660,625 to the University of Connecticut Health Center on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the cellular and molecular mechanisms of cerebellar hemisphere development. The research will examine how different granule cell progenitor populations interact with Purkinje cell subtypes to generate the folds and lobules of the cerebellar cortex, and how growth-controlling signaling pathways, particularly FGF-ERK signaling, regulate hemisphere-specific progenitor behavior and drive extended growth of the cerebellar hemispheres. The work builds on prior findings identifying multiple types of Purkinje cells that act as local organizers of cerebellar development and diverse granule cell progenitor populations, including a quiescent, long-lived pool linked to hemisphere formation. Understanding this development is relevant to conditions such as autism, dyslexia, and learning disabilities that disrupt cerebellar hemispheres, which contribute to movement, sensory processing, attention, language, and higher cognitive functions. The award period extends from September 1, 2026, through June 30, 2031. Performance takes place in Farmington, Connecticut.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $660.6k | 8/26/26 |