Project Grant R56NS143806
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $230,985 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) for a project examining alternative splicing of ion channels in the human brain. The project profiles the ion channel transcriptome and studies how alternative splicing affects neuronal physiology. Aim 1 combines long-read RNA sequencing and transcript capture technology...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Northwestern University $564,007 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate multi-region neural dynamics of internally driven timing decisions at spiking resolution. The research addresses how distributed networks of brain regions interact during...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded Northwestern University $117,145 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on the neural dynamics underlying self-generated action decisions under uncertainty. The research investigates how the brain determines when and where to act in...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $534,666 on July 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate how the primary motor cortex directly influences muscle activity during naturalistic motor behaviors. The research develops and applies a novel technical approach combining rapid silencing of motor cortical output with electromyographic muscle activity...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $634,938 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate RNA editing dysregulation in dementia with Lewy bodies and Parkinson's disease. The research addresses how proteostasis failure in these neurodegenerative conditions leads to accumulation of nuclear inclusions containing RNA binding proteins NONO and SFPQ,...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $240,000 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to characterize human TRIO isoforms and their role in synapse development. The research leverages long-read sequencing, induced pluripotent stem cell models, and fluorescence imaging to catalog TRIO isoform diversity, expression patterns, and domain architectures. TRIO...
- Federal Project Grant Award Summary Northwestern University received a $438,606 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025 through July 31, 2027. The research project focuses on establishing induced pluripotent stem cell (iPSC)-based models to investigate the mechanistic interaction between neurotrauma and amyotrophic...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Northwestern University $630,651 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the molecular mechanisms of magnesium transport in neuronal homeostasis. The research defines the structure and transport mechanism of CNNM (cyclin and CBS domain magnesium...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded ST Jude Children's Research Hospital Inc. $690,296 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate nuclear condensation and chromatin reorganization during cerebellar granule neuron differentiation. The research employs three integrated approaches: innovative CMAP epigenetic imaging probes to...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $620,507 on August 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the association between TDP-43 dependent disruptions in RNA metabolism and neuronal excitability in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research tests the hypothesis that TDP-43 dependent splicing errors on UNC13A...
The National Institute of Neurological Disorders and Stroke awarded Northwestern University $509,949 on August 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support basic research elucidating mechanisms of chromosomal organization in control of neuronal connectivity in the brain. The funded research investigates mega-enhancer bodies (ME bodies) that compartmentalize neuronal long genes encoding synaptic proteins within nuclear microenvironments in granule neurons in the cerebellum. The work includes determining how the transcription factor ETV1 controls ME body formation and recruits genomic loci to these structures to activate gene expression programs promoting granule neuron maturation. The research also defines the biological functions of neuronal long genes and ME bodies in establishing distinct granule neuron subtypes in anterior and posterior cerebellar lobules, testing hypotheses that subtype-specific transcription factors regulate neuron specification and recruit target long genes to ME bodies in subtype-specific manner, and examining whether subtype-specific long genes establish distinct neural circuit connectivity. Performance occurs at Northwestern University's Evanston, Illinois campus. The award period runs from August 21, 2026, through July 31, 2027. The assistance type is Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $509.9k | 8/21/26 |