This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a new therapy for neurodevelopmental mitochondrial disorders. The $105,625 award to the Icahn School of Medicine at Mount Sinai, from August 1, 2024 to July 31, 2026, will support two main objectives: 1) analyzing how a specific succinyl-CoA precursor is...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to develop novel biomarkers for tracking plexiform neurofibroma tumor burden in individuals with neurofibromatosis type 1 (NF1). The $734,542 award will be used to perform analytical validation studies of candidate biomarker signatures, specifically...
This federal Project Grant award of $985,026 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to investigate the roles and mechanisms of epitranscriptomic regulation in the development and function of the mammalian nervous system, as well as the pathological consequences of disrupting these processes. The research program will utilize mouse models and human induced...
This federal Project Grant award of $684,451 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, to Weill Medical College of Cornell University. The award supports a 5-year research project aimed at: 1) identifying progression subtypes of Parkinson's disease (PD) through integrative modeling of longitudinal clinical, transcriptomic, and neuroimaging data;...
This federal Project Grant award, totaling $826,742, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to elucidate the structural and molecular basis of the CHCHD10 protein's aggregation and its role in the pathogenesis of frontotemporal dementia. Key objectives include investigating the atomic-resolution structures of...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) provides $1,049,035.00 to The Children's Hospital of Philadelphia to harmonize and curate a natural history database for Metachromatic Leukodystrophy (MLD), a rare and fatal neurological disease. The project aims to create a rigorous, regulatory-ready database (MLD-CORE) and a public web platform (MLD-LINK) to...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,216,094 in funding to the University of California, San Diego to investigate a novel mechanism of dysfunctional mitophagy (selective autophagy of mitochondria) and its role in brain ischemia-reperfusion injury. The objective is to determine if inactivation of the...
This Project Grant award, with a total funding amount of $667,644, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research at the Icahn School of Medicine at Mount Sinai to further the understanding of cortical lesion formation and repair in early multiple sclerosis (MS), and their impact on physical and cognitive...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $272,000.00 to support a Clinical Trials Methodology Course in Neurological Disorders (CTMC). The goal of this training program is to supply the healthcare system with effective clinical researchers and biostatisticians capable of implementing well-designed clinical...
This federal Project Grant award of $897,250 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research focused on understanding the role of biomolecular condensates, such as ribonucleoprotein (RNP) granules, in governing RNA metabolism and their relationship to neurological diseases. The 8-year research program, led by St. Jude Children's Research Hospital...
This federal Project Grant award of $169,000 from the National Institute of Neurological Disorders and Stroke (NINDS, CFDA 93.853) will support the development of a comprehensive, open-source, and user-friendly online platform for neurometabolic diseases. The platform will include clinical, biochemical, radiological, and therapeutic data on over 1,600 known neurometabolic diseases. This initiative aims to enhance understanding, clinical management, and research insights into these rare genetic conditions that can lead to significant neurological deficits. The award will fund a multidisciplinary team at the Icahn School of Medicine at Mount Sinai, which has expertise in clinical neurometabolism, chemical analysis, bioinformatics, and software engineering. The project period runs from September 2024 to August 2026.