Project Grant R01NS145389
- This $407,113 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to develop new potassium channel modulators to reduce neuronal overexcitation and mitigate chronic pain. The award, granted to the University of California, Irvine, funds research to identify and validate compounds that can stabilize the interaction between potassium channels...
- This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), supports research to understand the molecular mechanisms underlying BK potassium channel dysfunction in neurological disorders. The $655,968 grant, awarded on April 21, 2025, will be used by researchers at Washington University to conduct a multi-year study investigating how...
- This federal Project Grant award of $525,436.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research on the structural pharmacology of GIRK channel disease mutants. The research aims to elucidate the molecular mechanisms underlying the loss of potassium selectivity and constitutive activation of GIRK2 channels associated with Keppen-Lubinsky syndrome, a...
- This $769,995 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Northwestern University to investigate the functional genetic basis of KCNB1 encephalopathy. This rare and severe neurodevelopmental disorder is characterized by developmental delay, intellectual disability, seizures, and elevated mortality risk. The research aims to...
- The federal Project Grant award titled "Pathophysiology of KCNQ2-Related Disorders" is funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $874,094 award supports research to determine how mutations in the KCNQ2 gene impair the assembly and physiology of neuronal potassium ion channels, with the goal of advancing the understanding of the...
- This federal Project Grant award of $147,486 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research at Baylor College of Medicine to define the molecular mechanisms responsible for clustering KV1 potassium channels at the axon initial segment (AIS). The research aims to elucidate how the localization of these ion channels at the AIS, which is critical for...
- This federal Project Grant award, titled "Structural and Functional Insights into Large-Pore Channels", was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The $732,475 award, effective from August 1, 2025 to April 30, 2030, supports research conducted by Cold Spring Harbor Laboratory to enhance the understanding of calcium homeostasis...
- This Project Grant award of $433,125.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research by The Ohio State University into the functional expression of the small conductance Ca2+-activated K+ channel, SK2, as a potassium channel that contributes to the passive potassium conductance in astrocytes. The project aims to correlate the SK2 channel gene...
- This $2,503,949 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Rockefeller University aimed at discovering therapeutic targets for neurological diseases. The project utilizes new techniques and concepts to study the fundamental mechanisms of brain disorders, focusing on how differences in cell-specific RNA regulation contribute to...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $377,262 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The University of Kentucky Research Foundation. The grant, awarded on August 15, 2025, supports research to investigate the mechanism underlying sphingoid base-induced neurotoxicity in neurodegenerative diseases. Specifically, the project will use a transgenic mouse model to dissect the...
This $580,619 Project Grant was awarded on August 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to investigate the molecular mechanisms underlying the pharmacological activation of KCa2 potassium channels, which are important for regulating neuronal excitability in the central nervous system. The research aims to: 1) Compare the mechanisms of action for classic positive allosteric modulators (PAMs) and superagonists of KCa2 channels, and 2) Identify novel KCa2 activators using virtual high-throughput screening and artificial intelligence/machine learning approaches. The grant was awarded to Chapman University, a private non-profit research university in California, to conduct this neuroscience research project over a period ending on June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $580.6k | 7/30/25 |