Project Grant R37NS138211
- The federal Project Grant award titled "Pathophysiology of KCNQ2-Related Disorders" is funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $874,094 award supports research to determine how mutations in the KCNQ2 gene impair the assembly and physiology of neuronal potassium ion channels, with the goal of advancing the understanding of the...
- This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), supports research to understand the molecular mechanisms underlying BK potassium channel dysfunction in neurological disorders. The $655,968 grant, awarded on April 21, 2025, will be used by researchers at Washington University to conduct a multi-year study investigating how...
- This federal Project Grant award of $525,436.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research on the structural pharmacology of GIRK channel disease mutants. The research aims to elucidate the molecular mechanisms underlying the loss of potassium selectivity and constitutive activation of GIRK2 channels associated with Keppen-Lubinsky syndrome, a...
- This Project Grant award of $207,387 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to characterize neocortical and hippocampal circuit dysfunction in a mouse model of epilepsy caused by variants in the KCNT1 gene. The primary awardee, the University of Vermont, will conduct simultaneous high-density electrophysiological and optogenetic testing to...
- This $580,619 Project Grant was awarded on August 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to investigate the molecular mechanisms underlying the pharmacological activation of KCa2 potassium channels, which are important for regulating neuronal excitability in the central nervous system. The research aims to: 1) Compare...
- This $630,414 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (CFDA 93.853) supports research at Northwestern University to investigate the role of sodium channel dysfunction in altered brain development. The research aims to phenotype the prenatal and postnatal impacts of pathogenic variants in the SCN2A and SCN3A sodium channel subtypes, using a ferret model system to study the biological basis of related neurological disorders. The award,...
- This federal Project Grant award of $147,486 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research at Baylor College of Medicine to define the molecular mechanisms responsible for clustering KV1 potassium channels at the axon initial segment (AIS). The research aims to elucidate how the localization of these ion channels at the AIS, which is critical for...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $195,000.00 to investigate the cellular mechanisms by which Long QT Syndrome-associated KCNH2 variants disrupt neuronal function. The award aims to use neurons differentiated from gene-edited and patient-derived human stem cells to determine how LQTS2-associated KCNH2 variants...
- This Project Grant award of $241,380 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to advance the understanding of neurodevelopmental disorders (NDDs) and develop innovative therapies. The research program, led by researchers at Boston Children's Hospital, will use single-cell epigenomic technologies to link pathogenic variants in chromatin regulators, such as...
- This $539,999 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to investigate the role of the NKX2.1 homeobox transcription factor in nervous system development. The research, to be conducted by Kennesaw State University, will utilize the nematode Caenorhabditis elegans as a model organism to better understand how NKX2.1 and related...
This $769,995 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Northwestern University to investigate the functional genetic basis of KCNB1 encephalopathy. This rare and severe neurodevelopmental disorder is characterized by developmental delay, intellectual disability, seizures, and elevated mortality risk. The research aims to enhance understanding of the classical ion-conducting and non-canonical signaling functions of the KCNB1-encoded Kv2.1 potassium channel, which play critical roles in neuronal excitability. This 4-year award, effective August 1, 2025, will fund investigations into the underlying molecular mechanisms and potential therapeutic approaches for KCNB1 encephalopathy, a significant unmet public health need.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $770.0k | 7/30/25 |