This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $258,498.00 to the University of California, Los Angeles (UCLA) to investigate the biological pathways linking sleep health to Alzheimer's disease and cognitive decline. The key objectives are to: Use a multi-omics approach to analyze methylation and metabolomics data associated with short sleep and insomnia among a high-risk Hispanic population, and compare the results to Alzheimer's...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $458,452 to the University of Utah to conduct research on the interrelationship between sleep, circadian rhythms, and substance use disorders. The key objectives are to: 1) determine the mechanisms of psychostimulant-induced sleep changes, 2) screen Drosophila orthologs of human brain-enriched transcripts for their role in...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) aims to examine the pathological white matter microstructural alterations and functional connectivity changes in the brain following exposure to the organophosphate compound diisopropylfluorophosphate (DFP). The $508,816 award will fund research to use high-resolution diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) to analyze the...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support a comprehensive scientific investigation to identify links between pesticide exposure and markers across the Alzheimer's disease and related dementias (ADRD) neurodegeneration continuum. The $2,368,557 award, effective March 15, 2025 through January 31, 2030, will leverage 30 years of environmental health data from the Agricultural Health Study (AHS) and...
This federal Project Grant award of $442,938, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research at the University of California, San Francisco (UCSF) to investigate the relationship between sleep, memory, and aging. The key objectives are to: 1) characterize how aging affects sleep patterns required for memory consolidation and synaptic plasticity during long-term memory formation; and 2) determine how upregulating the unfolded protein response can...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research aims to study the impact of post-concussive sleep disruption on glymphatic function in collegiate athletes. The $1,544,840 award, effective April 4, 2025 through January 31, 2030, will fund research to: 1) define pre-morbid risk factors for post-concussive sleep-wake disturbance; 2) establish the combined effects of concussion and post-concussive sleep...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,498,158 to Synaptic Health LLC to develop a novel closed-loop feedback neuromodulation system to improve slow wave sleep in Alzheimer's disease patients. The goal of this Phase I project is to create a testable prototype that can sense sleep architecture and provide peripheral neuromodulation stimulation to individuals over 65, a high-risk group for Alzheimer's disease. Successful...
This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research into the molecular interplay of sleep and neurodegeneration using the Drosophila model system. With $2.14 million provided over 11 months, the Trustees of the University of Pennsylvania will investigate how expression of the TDP-43 protein linked to neurodegenerative diseases disrupts sleep in fruit flies. Researchers will aim to define the specific glial subtypes...
This $2,965,125 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) aims to determine how neuronal population dynamics during non-rapid-eye-movement sleep (NREMS) regulate cortical-striatal coupling and impact behavioral automaticity versus flexibility. The project, titled "ROLE OF COORDINATED MULTI-AREA REACTIVATIONS DURING TRANSITIONS BETWEEN AUTOMATIC AND FLEXIBLE BEHAVIORS", is funded under the 21st Century Cures Act - Brain Research...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $667,865 to The Johns Hopkins University to conduct research on the role of microglial glutaminase in HIV-induced sleep deficits. The research aims to: 1) characterize sleep phenotypes in murine models of HIV infection, 2) analyze microglial activation, neuronal activity, neuroinflammation, and microglial transcriptomes in these...