This $7.72 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Seattle Institute for Biomedical and Clinical Research will define the role of post-traumatic brain injury sleep disruption and glymphatic dysfunction in the development of Alzheimer's disease and chronic traumatic encephalopathy neuropathology. Over three years, the grantee and three sub-awardees will...
This federal Project Grant award of $711,226 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to examine brain changes in individuals with obstructive sleep apnea (OSA). The key objectives are to: 1) investigate regional brain temperatures, metabolites, and antioxidant levels in OSA patients compared to healthy controls; 2) determine relationships between brain changes and disease severity; and 3) assess...
This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop subject-specific brain injury models to study sex differences in concussion and subconcussion biomechanics. The $183,402 award to Worcester Polytechnic Institute (WPI) will be used to create whole brain and axon-level computational models to characterize...
The federal Project Grant award R01HL174653, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports a longitudinal outcomes study focused on understanding the impact of pain and sleep disturbances on executive function (EF) outcomes in children who have survived pediatric intensive care unit (PICU) hospitalization. The $737,030 award will be used to identify pain trajectories and biopsychosocial risk factors,...
The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) awarded a $133,410 Project Grant (R21HL175584) under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Massachusetts Medical School to investigate the impact of sleep pathology on cardiac aging. The 2-year research project, running from September 2024 to August 2026, will leverage a large longitudinal dataset to assess the association between sleep apnea and cardiac...
The Department of Defense, through the Military Medical Research and Development program (CFDA 12.420), awarded a $674,746 Project Grant to the Seattle Institute for Biomedical and Clinical Research. The grant, titled "GLIMPSE-PD: GLYMPHATICS IMAGING TO PROBE SLEEP IN PARKINSON'S DISEASE", aims to investigate glymphatic function and sleep disruption in Parkinson's disease. The research will leverage expertise and resources from the University of Washington, where a $214,688 sub-award...
This federal Project Grant award of $253,500 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop and validate a low-profile, wearable sensor system called "SleepTronix" for the ambulatory assessment of sleep, temperature, and cortisol levels. The primary objective is to create an accurate, non-commercial solution to characterize the underlying pathophysiology of obstructive sleep apnea (OSA),...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,408,372 to the University of Washington to develop and evaluate a technology-based sleep self-management intervention for adults with subarachnoid hemorrhage. The key objectives are to: 1) tailor an existing sleep intervention to meet the unique needs of subarachnoid hemorrhage survivors, 2) develop a technology-based version...
The National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), awarded a $696,470 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to the University of Denver. The goal of this 4.5-year project is to investigate the relationship between prenatal maternal sleep patterns and offspring cardiovascular disease risk factors. Specifically, the researchers will examine how prenatal maternal sleep trajectories influence maternal...
This federal Project Grant award, in the amount of $332,862.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant, titled "NIGHT-TO-NIGHT VARIABILITY IN SLEEP DISORDERED BREATHING: SEX AND GENDER-RELATED PREDICTORS AND IMPACT ON OBSTRUCTIVE SLEEP APNEA CLINICAL HETEROGENEITY", aims to assess night-to-night variability in novel obstructive sleep apnea (OSA) severity metrics and their impact...