Project Grant R01NS144283
- The National Institute of Neurological Disorders and Stroke awarded Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, $1.84 million on September 5, 2026, to investigate phosphodiesterase 2A signaling in traumatic brain injury and Alzheimer's disease under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project examines how phosphodiesterase 2A modulates voltage-dependent anion channel 1...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Iowa State University of Science and Technology $393,447 on July 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate disease-modifying effects of NRF2 activators in organophosphate nerve agent exposure models. The research tests whether combining neuroprotectants with current medical countermeasures will prevent long-term neurotoxicity and epilepsy development...
- The National Institutes of Health Office of the Director awarded the University of Tennessee Health Science Center $403,972 under the Trans-NIH Research Support program (CFDA 93.310) on August 15, 2026, to define mechanistic pathways through which arsenic trioxide disrupts brain and cognitive function and to identify novel therapeutic strategies to prevent or mitigate delayed neurotoxic consequences of exposure. Research focuses on the integrated stress response and stimulator of interferon...
- The National Institutes of Health Office of the Director awarded Texas A&M University System Health Science Center $423,500 on June 12, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate 2-deoxyglucose therapy as an adjunct neuroprotectant to midazolam in mitigating long-term neurological effects from acute organophosphate pesticide and nerve agent exposure. The project seeks to identify glycolysis inhibition as a novel countermeasure by testing the...
- The National Institutes of Health Office of the Director awarded University of California, Davis $468,559 on August 20, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate JAK/STAT signaling as a therapeutic target to mitigate long-term neurological effects of acute organophosphate intoxication. The research tests whether pharmacological inhibition of STAT3 can reduce spontaneous recurrent seizures and cognitive decline following organophosphate exposure. Using a...
- The National Institute of Neurological Disorders and Stroke awarded Rutgers The State University of New Jersey $617,246 on September 26, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the toxicity of lipid-rich alpha-synuclein inclusions in Parkinson's disease pathology. The research examines Lewy bodies and related lipid-rich alpha-synuclein inclusions prevalent in the substantia nigra and brainstem regions....
- The National Institute of Neurological Disorders and Stroke awarded Rutgers The State University of New Jersey (RBHS-School of Nursing) $787,111 on September 5, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate a humanized antisense oligonucleotide (ASO) targeting nerve injury-specific long non-coding RNA (NIS) as a non-opioid, non-addictive analgesic for chronic neuropathic pain. The R61 phase includes design, synthesis, and purification of...
- The National Institute of Neurological Disorders and Stroke awarded Rutgers The State University of New Jersey $1.872 million on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate fibrinogen-mediated mechanisms in cerebral amyloid angiopathy. The research elucidates molecular mechanisms underlying cerebral amyloid angiopathy, a cerebrovascular pathology affecting over 80 percent of Alzheimer's disease...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, awarded Rutgers The State University of New Jersey, School of Nursing, $474,749 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the molecular and cellular mechanisms governing functional maturation and adult subtype diversification in spinal motor neurons. The project addresses postnatal...
- The National Institute of Neurological Disorders and Stroke awarded Rutgers, The State University $118,593 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing). The award funds research investigating the role of dorsal horn interneurons expressing the serotonin 6 receptor (5HTR6+ interneurons) in sensorimotor integration within the spinal cord under both normal conditions and following spinal cord...
The National Institutes of Health Office of the Director awarded $471,000 to Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, on August 15, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to support Project Grant R01NS144283 investigating astrocyte-based mechanisms of organophosphate poisoning. The award funds research examining how astrocytes—glial cells abundant in the brain—contribute to injury from acute organophosphate exposure, including nerve agents and pesticides. The project tests the hypothesis that astrocyte activation plays a causative role in organophosphate-induced brain injury by studying adenosine metabolism and adenosine A2A receptor signaling in glial activation. The research builds on prior work on maladaptive adenosine processes in epileptogenesis and neurodegeneration, with the goal of identifying therapeutic agents that interfere with A2AR function or associated downstream pathways to counter organophosphate neurotoxicity. Acute organophosphate exposure causes acute seizures, status epilepticus, and motor and cognitive impairment; currently no effective countermeasure exists, attributed largely to insufficient mechanistic understanding of organophosphate-induced brain injury. Performance of the work occurs in Newark, New Jersey. The award runs from August 15, 2026, through June 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $471.0k | 8/17/26 |