Project Grant R01NS144157
- The National Institute of Neurological Disorders and Stroke awarded the University of California, Los Angeles $495,164 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research investigating mechanisms of Schwann cell development and plasticity in peripheral nerve regeneration. The research focuses on the MITF transcription factor as an injury-induced regulator of Schwann cell plasticity. The project will use...
- The National Institute of Neurological Disorders and Stroke awarded The Scripps Research Institute $710,155 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate post-transcriptional mechanisms of cortical inhibitory interneuron development. The research focuses on identifying how microRNA-mediated regulation controls interneuron migration and specification during development. The work employs engineered...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, San Diego $129,186 on July 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate metabolic plasticity and neuronal resilience in response to chronic mitochondrial DNA damage. The research will characterize mitochondrial DNA distribution and motility in healthy versus mitochondrial DNA-compromised neurons using two...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $126,900 on March 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to exploit RNA biogenesis, specifically alternative splicing programs, to accelerate maturation of human neurons in vitro and to develop models of age-related tauopathies. The research addresses a fundamental...
- The National Institute of Neurological Disorders and Stroke awarded the University of Southern California $1.245 million on August 18, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate mechanisms of differential vulnerability in the central nervous system and their implications for translating preclinical findings to successful clinical trials. The research examines why neurons, glia (astrocytes and microglia),...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services, awarded $429,000 to The Regents of the University of Colorado, doing business as University of Colorado-Denver, on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Program Grant R21NS151067). The award funds research on transcriptional and epigenetic regulation of neural progenitor fates during...
- The National Institute of Neurological Disorders and Stroke awarded Northern California Institute For Research And Education, Inc. (NCIRE) $414,464 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on sleep-dependent modulation of transplanted neural circuits for stroke recovery. The project characterizes the integration of human induced pluripotent stem cell (iPSC)-derived neurons transplanted...
- The National Institute of Neurological Disorders and Stroke awarded The Salk Institute for Biological Studies $150,104 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop methods for growing brain organoids with improved structural complexity, cellular diversity, and long-term viability. The project, titled "3D Printing Hydrogel Vasculature and Bioactive Cues Within Brain Organoids," addresses...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, Davis $622,252 on August 20, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to fund research into the functional biology of alternative promoters in the cerebral cortex. The research investigates how alternative promoters—multiple transcription start sites present in over half of human genes—regulate isoform selection and drive...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $642,712 to The University of Texas Southwestern Medical Center on June 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate adult neurogenesis as a strategy for improving urinary function after contusion spinal cord injury. The project systematically examines...
The National Institute of Neurological Disorders and Stroke awarded the University of California, Los Angeles $639,095 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on temporal control of neurogenesis termination in developing mammalian brains. The research investigates the molecular mechanisms by which neural stem cells, or radial glia, cease generating neurons shortly after birth—a process that occurs in both mice and humans and severely limits the adult brain's regenerative capacity. The project examines how neural stem cells regulate the timing of their own shutdown and what molecular signals drive their transformation into other cell types. Understanding these control mechanisms aims to identify molecular targets for maintaining or extending neurogenesis duration in transplanted neural stem cells, potentially enabling next-generation stem cell therapies for neurological disorders including stroke. Work is performed at UCLA in Los Angeles, California. The period of performance runs from August 15, 2026, through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $639.1k | 8/11/26 |