Federal Grant Award Summary

The National Institute of Neurological Disorders and Stroke (NINDS) awarded University of California, Los Angeles a Project Grant totaling $495,164 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award, effective June 1, 2026, through May 31, 2031, supports research investigating the mechanisms of Schwann cell development and plasticity in peripheral nerve regeneration. The research focuses on characterizing how the MITF (Microphthalmia-associated Transcription Factor) transcription factor integrates injury-derived signaling to drive Schwann cell reprogramming into repair cells, which is essential for axonal regeneration and functional recovery following peripheral nerve injury. Using integrated molecular, genetic, imaging, transcriptomic, and proteomic approaches, the investigators will elucidate how extracellular injury signals are transmitted through cytoplasmic cascades to modulate nuclear transcriptional programs that enable effective repair cell formation.

This research addresses a significant clinical gap in understanding peripheral nervous system disorders that impair motor function and alter pain sensitivity. By identifying the molecular mechanisms controlling Schwann cell plasticity, the project aims to advance therapeutic development strategies for peripheral nerve regeneration, ultimately contributing to more effective treatment approaches for currently incurable peripheral nerve injuries and diseases.