Project Grant R21NS147041
- This $2,965,125 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) aims to determine how neuronal population dynamics during non-rapid-eye-movement sleep (NREMS) regulate cortical-striatal coupling and impact behavioral automaticity versus flexibility. The project, titled "ROLE OF COORDINATED MULTI-AREA REACTIVATIONS DURING TRANSITIONS BETWEEN AUTOMATIC AND FLEXIBLE BEHAVIORS", is funded under the 21st Century Cures Act - Brain Research...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $433,125 to the University of Texas Health Science Center at San Antonio on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of REST (Restrictive Element-1 Silencing Transcription Factor) in governing post-stroke neural plasticity and recovery. The...
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $216,025 on February 13, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support a five-year career development investigation into neural circuit mechanisms underlying impaired memory consolidation after sleep loss. Dr. Jessica Jimenez, a clinical fellow in neurology at UCSF's Division of Sleep...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health under the Department of Health and Human Services, awarded $661,867 to The Trustees of Columbia University in the City of New York on August 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to develop electroencephalography-based sleep biomarkers for predicting recovery trajectories in patients with...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (Massachusetts General Hospital) $648,672 on June 11, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate circadian regulation of reperfusion efficacy in acute ischemic stroke. The research employs a translational approach combining clinical neuroimaging, biomarkers, mouse models of stroke, CT-PET imaging of tissue...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $594,435 to Oregon Health & Science University on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on pericyte phenotypic switching in diabetic post-stroke cognitive impairment. The project, R01NS146933, investigates the cellular and molecular...
- The National Institute of Neurological Disorders and Stroke awarded the University of Texas at Austin $393,284 on June 13, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct basic research on synaptic structural plasticity and stroke rehabilitation. The project examines how the brain remodels neural circuitry following stroke, with focus on reactive synaptogenesis—the growth of new connections among surviving neurons near...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, Los Angeles $639,095 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on temporal control of neurogenesis termination in developing mammalian brains. The research investigates the molecular mechanisms by which neural stem cells, or radial glia, cease generating neurons shortly after birth—a process...
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $617,439 on July 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to examine how lesion location and extent affect post-stroke neuroplasticity and recovery mechanisms. The project will use rat stroke models with varying lesion sizes and locations—systematically manipulating damage to the corticospinal tract and lesions in the cortex...
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $238,680 on July 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to dissect neural circuits regulating sleep fragmentation in Parkinson's disease. The award funds electrophysiologic research into sleep disturbances in a mouse model of Parkinson's disease, focusing on the pedunculopontine nucleus as...
The National Institute of Neurological Disorders and Stroke awarded Northern California Institute For Research And Education, Inc. (NCIRE) $414,464 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on sleep-dependent modulation of transplanted neural circuits for stroke recovery. The project characterizes the integration of human induced pluripotent stem cell (iPSC)-derived neurons transplanted into stroke-affected mouse brains, studying neural dynamics during sleep and wake states using dual-color calcium imaging to identify sleep-specific oscillations that promote synaptic plasticity and functional connectivity between transplanted and host neurons. A second research aim compares open-loop versus closed-loop electrical stimulation during sleep and behavior on neural coupling, integration, and motor recovery, hypothesizing that closed-loop stimulation aligned with intrinsic neural activity enhances recovery. The work employs wearable dual-color calcium imaging miniscopes and closed-loop stimulation interfaces to monitor and modulate neural activity in real-time, with the goal of identifying mechanisms supporting neural integration and informing personalized, activity-dependent therapies for stroke rehabilitation. NCIRE, a San Francisco-based nonprofit research organization, serves as the prime recipient. Performance occurs in San Francisco, California. The period of performance runs September 1, 2026, through August 31, 2028. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $414.5k | 8/25/26 |