Project Grant R01NS144133
- This federal Project Grant award, issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $4,693,249 to the University of California, Los Angeles (UCLA) to conduct research on defining the molecular spectrum of white matter vascular lesions that drive vascular cognitive impairment and dementia (VCID). The project aims to develop a better understanding of...
- The National Institute of Neurological Disorders and Stroke awarded Indiana University Indianapolis $165,512 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate platelet-mediated mechanisms of vascular injury in vascular contributions to cognitive impairment and dementia (VCID). The research will assess platelet activation and vascular interactions in two VCID mouse models—diet-induced hyperhomocysteinemia...
- This Project Grant award for $2,398,590.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of brain microcirculation and capillary endothelial cell energetics in the development of vascular cognitive impairment and dementia (VCID) observed in Alzheimer's disease (AD) and AD-related dementias. The...
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $618,108 on June 18, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on neuroinflammation in cerebral small vessel disease, a leading vascular contributor to cognitive impairment and dementia. The recipient will evaluate the relationship between 11C-CS1P1 PET uptake—a novel positron emission tomography radiotracer...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Albany Medical College $1.951689 million on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of inflammation-resolution pathways to address vascular contributions to cognitive impairment and dementia (VCID) in the context of atherosclerosis....
- The National Institute on Aging (NIA) awarded a $2,244,471 Project Grant under CFDA 93.866 (Aging Research) to Oregon Health & Science University (OHSU) to develop a first-in-class, CNS-penetrant small molecule agonist for G protein-coupled receptor 39 (GPR39) as a potential treatment for vascular cognitive impairment and dementia (VCID). The 3-year project from September 2023 to August 2026 will use in vitro and in vivo assays to identify lead compounds, determine their safety and...
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $190,080 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining the relationships between economic instability, epigenetic aging, and vascular contributions to cognitive impairment (VCID) across the adult lifecourse. The project applies causal inference methods...
- The National Institute of Neurological Disorders and Stroke awarded $242,250 to the University of Virginia on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award funds research into myeloid cell regulation of cerebrovascular tone and function, specifically investigating how microglia and perivascular macrophages maintain baseline vascular structure and blood flow in the brain and facilitate vascular responses...
- The National Institute of Neurological Disorders and Stroke awarded Weill Medical College of Cornell University $603,264 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate endothelial sphingolipid signaling in cerebrovascular inflammation and cognitive decline. The project examines how sphingosine-1-phosphate receptor signaling in cerebrovascular endothelial cells regulates blood-brain barrier function...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Illinois a $2.55 million Project Grant under the Aging Research program (CFDA 93.866) on August 11, 2025, with a completion date of July 31, 2029. This research project investigates the mechanisms by which SARS-CoV-2 infection increases the risk of vascular contributions to cognitive impairment and dementia (VCID). The research will examine how COVID-19 weakens the blood-brain barrier (BBB) through...
The National Institute of Neurological Disorders and Stroke awarded the University of Washington $647,418 under Project Grant R01NS144133 on August 27, 2026, to investigate the interaction between atherosclerotic plaque composition, reduced brain perfusion, and cognitive decline in vascular cognitive impairment and dementia (VCID). The award funds research to identify and characterize two distinct mechanisms driving VCID in patients with asymptomatic carotid and intracranial atherosclerosis: hemodynamic VCID (H-VCID), caused by reduced brain blood flow, and thromboembolic VCID (T-VCID), caused by high-risk plaque components that embolize to distal brain vessels. The research employs vessel wall MRI to quantitatively assess high-risk carotid plaque composition and novel intracranial artery flow measures (iCAFE) to evaluate blood flow changes in large and medium-sized intracranial arteries, with the goal of early identification of high-risk plaque before thromboembolic brain damage occurs and comprehensive assessment of both VCID pathways and intracranial macrovasculature status. The award funds a Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). Performance occurs at the University of Washington Office of Sponsored Programs in Seattle, Washington, with a period of performance through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $647.4k | 8/26/26 |