Project Grant R01NS147357
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Albany Medical College $1.951689 million on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of inflammation-resolution pathways to address vascular contributions to cognitive impairment and dementia (VCID) in the context of atherosclerosis....
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $618,108 on June 18, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on neuroinflammation in cerebral small vessel disease, a leading vascular contributor to cognitive impairment and dementia. The recipient will evaluate the relationship between 11C-CS1P1 PET uptake—a novel positron emission tomography radiotracer...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $198,164 to Weill Medical College of Cornell University on September 15, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of heme in oxidative modification of mRNA in neurodegenerative disease. The research examines how heme binds to G-quadruplex sequences...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded $671,988 to the Winifred Masterson Burke Medical Research Institute, Inc. on September 11, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The recipient will conduct research on cross-talk between sarmoptosis and ferroptosis in hemorrhagic stroke, specifically...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded Weill Medical College of Cornell University $172,260 on July 1, 2026, under the Aging Research program (CFDA 93.866) to characterize the relationship between electroencephalographic burst-suppression and postoperative delirium in the context of corticothalamic function. The recipient will investigate biomarkers for postoperative delirium, a neurocognitive disturbance...
- The National Institute of Neurological Disorders and Stroke awarded $574,660 to Icahn School of Medicine at Mount Sinai on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate neutrophil extracellular trap mitigation in ischemic stroke outcomes. The research addresses vascular contributions to cognitive impairment and dementia following acute ischemic stroke by examining how neutrophils form extracellular...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded the University of Cincinnati $654,628 on March 6, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to characterize the peripheral and immune-cell proteome in intracerebral hemorrhage patients and identify biomarkers and mechanisms associated with vascular cognitive...
- The National Institute of Neurological Disorders and Stroke awarded the University of Rochester $1,606,088 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate spatiotemporal control of cerebral blood flow by purinergic signaling networks. The project examines neurovascular coupling—the process by which cerebral blood flow rapidly directs to active brain regions to meet metabolic demands—with specific focus...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Yale University $667,613 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining ferroptosis—iron-induced programmed cell death—in erythrocytes within intracerebral hemorrhage hematomas. The project investigates how heme induces...
- The National Institute of Neurological Disorders and Stroke awarded Weill Medical College of Cornell University $122,850 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of progranulin microglial replacement therapy in Parkinson's disease. The research establishes a therapeutic paradigm using induced pluripotent stem cell–derived microglia that overexpress progranulin and evaluates their...
The National Institute of Neurological Disorders and Stroke awarded Weill Medical College of Cornell University $603,264 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate endothelial sphingolipid signaling in cerebrovascular inflammation and cognitive decline. The project examines how sphingosine-1-phosphate receptor signaling in cerebrovascular endothelial cells regulates blood-brain barrier function during systemic inflammation and its contribution to cognitive impairment. The research addresses a gap in understanding the cellular and molecular mechanisms whereby peripheral inflammatory factors signal through the cerebrovascular endothelium to alter cognitive function, with the goal of identifying therapeutic targets for dementia prevention and treatment. The proposal responds to clinical evidence that up to 50 percent of patients recovering from severe systemic inflammation, particularly elderly patients, develop persistent cognitive impairment and accelerated dementia. The award funds investigator-initiated basic research at Weill Medical College's New York location. The period of performance extends from September 1, 2026, through August 31, 2031. This is a Project Grant, a standard NIH research mechanism for independent investigator-led projects reviewed on scientific merit by peer panels and the National Advisory Neurological Disorders and Stroke Council.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $603.3k | 8/20/26 |