This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and...
This federal Project Grant award of $985,026 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to investigate the roles and mechanisms of epitranscriptomic regulation in the development and function of the mammalian nervous system, as well as the pathological consequences of disrupting these processes. The research program will utilize mouse models and human induced...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $376,355.00 to Albany Medical College to investigate the role of microglial insulin-like growth factor 1 (IGF1) in epileptogenesis. The research aims to characterize how elevated mTOR signaling in microglia leads to increased IGF1 expression, which then propagates mTOR signaling to...
This Project Grant award of $397,500.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to study fundamental principles connecting neurodevelopmental processes to the functional organization of neural circuits. The goal is to understand how these principles could enable network-scale regeneration, which has important implications for regenerative...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $489,500.00 to The Children's Hospital Corporation (Boston Children's Hospital) to conduct research on the discovery of stimulus-responsive microproteins in human microglia. The goal of this 2-year award (July 1, 2025 - June 30, 2027) is to elucidate how human microglia-like...
The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services, awarded a $4,528,840 Project Grant to The Salk Institute For Biological Studies under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The three-year award beginning August 19, 2022 will fund research to functionally dissect cerebellar output circuits that orchestrate limb motor control. Specifically, the grantee will...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $596,937.00 to investigate the role of the FMRP protein in regulating mitochondrial function and energy metabolism in human neuron development. The research aims to elucidate the mechanisms by which FMRP and its target RACK1 regulate activity-dependent mitochondrial...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a new therapy for neurodevelopmental mitochondrial disorders. The $105,625 award to the Icahn School of Medicine at Mount Sinai, from August 1, 2024 to July 31, 2026, will support two main objectives: 1) analyzing how a specific succinyl-CoA precursor is...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,830,581 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to The Johns Hopkins University. The grant supports in-depth characterization of the mechanism of action of a new macrocycle molecule called RAPIREON, which selectively activates the nuclease activity of the IRE1 protein in the unfolded protein response (UPR) pathway....
This federal Project Grant award of $656,513.00, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to identify germline modifiers of neurofibromatosis type 1 (NF1) tumors. The primary grantee, Childrens Hospital Medical Center, will work with a multidisciplinary team to expand the patient cohort with plexiform neurofibromas and/or optic...