Federal Grant Award Summary

Baylor College of Medicine received a $624,825 Project Grant award from the National Institute of Neurological Disorders and Stroke under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective March 15, 2026, with a completion date of February 28, 2031. The award supports research focused on developing computational methods to characterize the electrophysiological and genomic profiles of gliomas, specifically addressing the knowledge gap regarding how electrophysiological properties of tumor cells contribute to glioma progression and patient outcomes.

The primary deliverables include the development of computational methodologies to integrate multi-modal data and systematically link molecular and electrophysiological states of glioma cells. The research utilizes patch-sequencing (patch-seq) technology, which couples electrophysiological recordings, morphological analysis, and single-cell RNA-sequencing (scRNA-seq) to characterize distinct tumor cell subtypes. These computational tools and analytical frameworks are designed to advance understanding of the mechanisms underlying electrophysiological function in both IDH (isocitrate dehydrogenase) mutant and wild-type glioma subtypes, ultimately contributing to improved prognostic and therapeutic strategies for these malignant brain tumors.