Cross-species comparison of cholinergic neuromodulation in mice and primates
Active Project Grant Awarded Last action
- Award ID
- R34NS137454
- Recipient
-
Baylor College Of Medicine UEI FXKMA43NTV21
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $725,924
Award facts
- Assistance listing
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- Completion date 69% complete
- Place of performance
- Houston, TX 77030, USA
Award details come from USAspending.gov.
Description
- Abstract
- The brain continuously regulates its internal states in order to efficiently and flexibly interact with the environment. Brain states vary at a global scale due to changes in arousal, whereas local changes are typically observed during selective attention. Although arousal and attention operate at different spatial scales, they have similar physiological signatures. However, the major limitation of our understanding of the impact of brain states on neuronal circuits is the fact that arousal and attention have mostly been studied separately and in different species. Indeed, despite clear similarities between neural correlates of arousal in the mouse and attention in the primate, research on brain states in the two species has proceeded largely in parallel, with very few direct collaborations between primate and rodent labs. Therefore, whether and how the mechanisms regulating brain states on different spatial scales intersect to jointly influence neuronal function and behavior is unknown. Furthermore, with few exceptions, attention and arousal have been typically examined in one brain area at a time, hence precluding our understanding of the coordination of brain states at global and local spatial scales, their neural mechanisms, and their influence on behavioral performance. Here, we propose to develop several technical capabilities that will allow US to study multiple features of brain state changes across quiescence, arousal, and attention in mice and monkeys. We will develop a workflow for performing large-scale electrophysiological and optical recordings from multiple cortical areas relevant for visual behavior, establish a complementary behavioral paradigm in both species, and validate an optogenetic approach to silencing feedback. These capabilities will allow US to test three central hypotheses in a subsequent R01: (1) brain state changes in the mouse are a subset of changes in the primate, with similar underlying mechanisms but different spatial scales (aim 1 ); (2) selective attention is built on top of mechanisms that mediate fast changes in global arousal (aim 2), and (3) feedback from higher areas onto specific neural cell types mediates selective attention and is gated by global neuromodulation (aim 3). These experiments a will generate a potentially transformative multi-modal dataset for understanding the mechanisms of attention and arousal at single cell resolution, which will also advance our understanding of dysfunctional brain states and their impact on neurological disorders.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $355,462 | |
| Original award | $370,462 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| The Methodist Hospital | $176,993 |
Quick answers
Who received award R34NS137454?
R34NS137454 was awarded to Baylor College Of Medicine by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on June 3, 2025.
How much is award R34NS137454 worth?
$725,924 has been obligated on R34NS137454.
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