Project Grant R01NS141307
- This federal Project Grant award of $414,305 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will fund research to identify key molecules and pathways underlying the process of epileptogenesis, with the goal of developing therapies to modify disease progression. The research leverages a novel algorithm called MAGIC combined with a large...
- This Project Grant award of $743,776 from the National Institute of Neurological Disorders and Stroke (NINDS, CFDA 93.853) supports research to determine whether and when ablating mutant cells that cause epilepsy can reverse the disease in mouse models of mTOR pathway disorders. The research aims to advance the development of AAV-mediated gene therapy approaches to treat intractable epilepsy caused by mTOR pathway mutations. This work builds upon almost two decades of the recipient...
- This $2,503,949 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Rockefeller University aimed at discovering therapeutic targets for neurological diseases. The project utilizes new techniques and concepts to study the fundamental mechanisms of brain disorders, focusing on how differences in cell-specific RNA regulation contribute to...
- This $614,009 federal Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research into the molecular mechanisms of oligodendrocyte myelination and remyelination, which are critical processes for addressing demyelinating diseases of the central nervous system like multiple sclerosis. The awardee, Children's Hospital...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $426,250 Project Grant under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders, to the Regents of the University of Minnesota, Office of Sponsored Projects Administration. This 2-year grant will fund research using cutting-edge voltage imaging to examine how interactions between specific neuronal circuit elements in the hippocampus relate to the development of temporal lobe...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $222,160 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of California, San Diego (UCSD). The grant will support Dr. Alena Stasenko's research to develop risk and resilience models of cognitive aging in epilepsy and novel, tech-based interventions to improve brain health. The project aims to leverage digital assessment to determine the...
- This $357,191 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to mechanistically link acute seizures with chronic alterations in cholinergic networks in a mouse model of Dravet syndrome. The primary objective is to delineate seizure-associated pathology in the cholinergic pedunculopontine nucleus (PPN) to identify targets for...
- This federal Project Grant award of $238,356 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to study the role of the amygdala-nucleus reticularis thalami (NRT) pathway in modulating thalamocortical circuits and cortical activity, and its potential impact on seizures and neuropsychiatric comorbidities in people with epilepsy. The research, led by the...
- This federal Project Grant award of $657,958 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting research into the cellular and network mechanisms of epilepsy and neuromodulation. The research team from Trustees of Boston University will use cutting-edge cellular membrane voltage imaging, optogenetics, and local field potential recordings in cortical...
- This federal Project Grant award of $390,000.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of dysregulated eIF4E-mediated translational control in the pathogenesis of Focal Cortical Dysplasia Type II (FCDII), a neurodevelopmental disorder that causes focal cortical malformations and drug-resistant epilepsy. The...
This $579,294 Project Grant was awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to understand the cell type-specific epigenetic mechanisms, particularly involving microRNAs, that regulate brain function and contribute to neurological disorders like epilepsy. The research aims to reveal the specific cell types and target mRNAs through which select microRNAs exert their effects on seizure control and neuronal morphology. This 5-year grant, awarded to the Children's Hospital Medical Center in Cincinnati, Ohio, began on August 1, 2025 and is scheduled for completion on July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $579.3k | 7/24/25 |