Project Grant R01NS140167
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $654,218 to the University of Maryland, Baltimore to support research on the mechanisms and intervention of cyclic GMP-AMP synthase (cGAS) signaling in traumatic brain injury (TBI). The research aims to investigate how the leakage of genomic and mitochondrial DNA into the brain after TBI...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders" provides $404,100.00 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to study the mechanisms of chronic blood-brain barrier dysfunction after traumatic brain injury (TBI). The research aims to identify a signaling pathway involving the...
- This Project Grant award for $453,860.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the metabolic regulation of neutrophil extracellular traps (NETs) in traumatic brain injury (TBI). The research aims to elucidate how AMPK activation protects the brain by reducing NET formation and inflammation following TBI, with the goal...
- This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to investigate the potential impact of a low-fat, high-fiber diet in limiting traumatic brain injury (TBI)-induced neurodegenerative and inflammatory changes in a mouse model. The $498,713.00 award, with a performance period from July 2024 to June 2027, will support research to...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $571,404.00 to the University of Pittsburgh to conduct research on the use of the adipokine hormone adiponectin as a potential therapy to promote functional recovery after traumatic brain injury (TBI). The funding will support investigations into the long-term impact and...
- This $380,556 federal Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research at East Carolina University to investigate the regulation of efferocytosis, the process of phagocytes removing apoptotic cell debris, in the brain following traumatic injury. The research aims to determine the temporal dynamics of...
- This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at The Ohio State University on the role of NF-kB in chronic inflammation, microglia priming, and neuropsychiatric complications following traumatic brain injury (TBI). The $132,609 award, which runs from September 1, 2025 to April 30, 2027, aims to explore...
- This federal Project Grant award of $453,970.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research to determine the effects of intranasal administration of the neurotrophic growth factor heparin-binding epidermal growth factor (HB-EGF) on brain glucose metabolism and inflammation following traumatic brain injury (TBI) in the developing brain. The...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $157,486 project grant to Case Western Reserve University (CWRU) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The project aims to investigate the interplay between traumatic brain injury (TBI), hematopoietic stem cell (HSC) dysfunction, chronic neurodegeneration, and Alzheimer's disease (AD). Specifically, the research will assess how acute TBI induces...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will support research to investigate the role of serotonergic signaling in the gut following traumatic brain injury (TBI). The $521,963 award to The Johns Hopkins University will fund a 5-year study to examine how changes in gut serotonin production and interactions with gut macrophages contribute to the neuroinflammatory response after TBI. The research aims to elucidate these gut-brain axis mechanisms and explore potential therapeutic approaches to restore serotonin signaling, such as through pharmacological or genetic interventions targeting the serotonin system. By advancing the understanding of the gut's involvement in the pathogenesis of TBI, this project seeks to provide insights that could inform the development of new treatment strategies for this significant public health concern.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $522.0k | 8/1/25 |