The University of Alabama at Birmingham (UAB), doing business as U A B, has been awarded a $556,661 Project Grant (R01NS133242) by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding supports research to investigate the role of thalamic microglia in cognitive impairment following cortical injuries, such as traumatic brain injury. Specifically, the project aims to elucidate the effects of cortical injury-induced microglial changes on thalamic neurons, demonstrate the restorative impact of removing thalamic microglia on recognition memory, and evaluate the effects of inhibiting microglial phagocytosis on thalamic neuronal pathology and cognitive deficits. The research findings are expected to provide novel insights into the critical thalamic pathology underlying long-term neurological deficits after traumatic brain injury. The project will be conducted at UAB and is scheduled for completion by May 31, 2029.
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