Project Grant R01NS137633

Award Date 9/18/24
Completion Date 6/30/29
Dollars Obligated $799K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Houston, TX 77030, USA
Similar Awards
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to establish the role of alpha-synuclein-mediated membrane permeabilization in the spread of alpha-synuclein aggregates related to Parkinson's disease and related dementias. The $406,260 award to Purdue University will leverage fluorescence lifetime imaging microscopy...
This federal Project Grant award of $670,600 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will support research at The Johns Hopkins University to investigate the role of microglia, a type of immune cell in the brain, in the onset and progression of Parkinson's disease (PD) and PD-related cognitive impairment. The key objectives are to...
This federal Project Grant award of $173,140 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to investigate the role of neural activity in the degeneration of midbrain dopamine neurons, which is a key feature of Parkinson's disease. The research project, which runs from September 30, 2024 to June 30, 2027, will utilize novel mouse models to...
This $475,475 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts. The goal of the award is to evaluate a small molecule inhibitor of the USP30 enzyme as a potential neuroprotective therapy for Parkinson's disease. The research will assess...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $646,104 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the San Diego Biomedical Research Institute, a non-profit research organization. The grant supports research to investigate how neuroinflammation mediated by the interleukin-13 receptor signaling pathway may contribute to the selective loss of dopaminergic neurons in Parkinson's disease. The...
This federal Project Grant award of $684,451 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, to Weill Medical College of Cornell University. The award supports a 5-year research project aimed at: 1) identifying progression subtypes of Parkinson's disease (PD) through integrative modeling of longitudinal clinical, transcriptomic, and neuroimaging data;...
This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to investigate the role of synaptic organizers in Parkinson's disease pathology and potential therapeutic interventions. The total funding amount is $669,115, awarded on September 1, 2024 with a project period ending on August 31, 2029. The research project, led by Texas A&M...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate the role of the GPNMB gene in the pathogenesis of Parkinson's disease, Lewy body dementia, and related synucleinopathies. The $655,329 award to the Albert Einstein College of Medicine aims to identify causal genetic variants that regulate GPNMB expression...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $2,208,982.00 to the San Diego Biomedical Research Institute to conduct research on the role of the interleukin-13 receptor (IL-13RA1) in regulating the viability of dopaminergic neurons and its potential contribution to Parkinson's disease pathogenesis. The key objectives are to...
This Project Grant award of $616,200.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The objective is to study the influence of neuromelanin, a dark pigment found in dopamine neurons, on the degeneration of these neurons in Parkinson's disease. The research will leverage a novel mouse model developed by a sub-awardee, Emory University,...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders" supports research focused on developing a nano scavenger-based diagnostic and therapeutic strategy for Parkinson's disease. The $799,127 award to Baylor College of Medicine aims to establish the preclinical potential of a nano scavenger agent that can bind to and facilitate clearance of pathogenic oligomeric alpha-synuclein species in the brain. The research will test the agent's ability to profile and halt disease progression in a transgenic mouse model from the prodromal stage through early to late stages, validating in vivo imaging results with ex vivo histology and behavioral studies. Additionally, the project will investigate the cellular mechanisms involved in uptake and degradation of the biomarker using murine and human cell lines. The findings are expected to advance understanding of Parkinson's disease pathogenesis and the potential of nano scavenger-based theranostic approaches.

Generated 7/1/25, 3:25 AM