This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to investigate the role of synaptic organizers in Parkinson's disease pathology and potential therapeutic interventions. The total funding amount is $669,115, awarded on September 1, 2024 with a project period ending on August 31, 2029. The research project, led by Texas A&M University System Health Science Center, will examine the effects of dopamine depletion on synaptic organizer expression and ultrastructural changes in striatal synapses in Parkinson's disease models. It will determine the relationship between synaptic organizer levels, synaptic properties, and motor/non-motor behaviors, as well as evaluate the potential for restoring normal synaptic signaling to mitigate behavioral deficits. The project involves collaborations with Arizona State University and Emory University through sub-awards to investigate novel antigen tests for diagnosing active Treponema pallidum infection and striatal trans-synaptic signaling mechanisms, respectively.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $669.1k | 8/30/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
M2403900S | Arizona State University | Project Grant R01NS133338 | $38.5k | 3/5/25 | |
M2500186S | Emory University | Project Grant R01NS133338 | $86.8k | 2/17/25 |