Project Grant R01NS137587
- This $769,995 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Northwestern University to investigate the functional genetic basis of KCNB1 encephalopathy. This rare and severe neurodevelopmental disorder is characterized by developmental delay, intellectual disability, seizures, and elevated mortality risk. The research aims to...
- This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), supports research to understand the molecular mechanisms underlying BK potassium channel dysfunction in neurological disorders. The $655,968 grant, awarded on April 21, 2025, will be used by researchers at Washington University to conduct a multi-year study investigating how...
- This federal Project Grant award of $525,436.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research on the structural pharmacology of GIRK channel disease mutants. The research aims to elucidate the molecular mechanisms underlying the loss of potassium selectivity and constitutive activation of GIRK2 channels associated with Keppen-Lubinsky syndrome, a...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $195,000.00 to investigate the cellular mechanisms by which Long QT Syndrome-associated KCNH2 variants disrupt neuronal function. The award aims to use neurons differentiated from gene-edited and patient-derived human stem cells to determine how LQTS2-associated KCNH2 variants...
- This $630,414 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (CFDA 93.853) supports research at Northwestern University to investigate the role of sodium channel dysfunction in altered brain development. The research aims to phenotype the prenatal and postnatal impacts of pathogenic variants in the SCN2A and SCN3A sodium channel subtypes, using a ferret model system to study the biological basis of related neurological disorders. The award,...
- This $580,619 Project Grant was awarded on August 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to investigate the molecular mechanisms underlying the pharmacological activation of KCa2 potassium channels, which are important for regulating neuronal excitability in the central nervous system. The research aims to: 1) Compare...
- This Project Grant award of $207,387 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to characterize neocortical and hippocampal circuit dysfunction in a mouse model of epilepsy caused by variants in the KCNT1 gene. The primary awardee, the University of Vermont, will conduct simultaneous high-density electrophysiological and optogenetic testing to...
- This federal Project Grant award of $147,486 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research at Baylor College of Medicine to define the molecular mechanisms responsible for clustering KV1 potassium channels at the axon initial segment (AIS). The research aims to elucidate how the localization of these ion channels at the AIS, which is critical for...
- This $579,294 Project Grant was awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to understand the cell type-specific epigenetic mechanisms, particularly involving microRNAs, that regulate brain function and contribute to neurological disorders like epilepsy. The research aims to reveal the specific cell types and target mRNAs...
- This federal Project Grant award, valued at $643,377.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to investigate cellular mechanisms of enteric nervous system damage in CLN2 disease, a rare neurodegenerative lysosomal storage disorder. The research aims to better understand how lysosomal dysfunction leads to...
The federal Project Grant award titled "Pathophysiology of KCNQ2-Related Disorders" is funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $874,094 award supports research to determine how mutations in the KCNQ2 gene impair the assembly and physiology of neuronal potassium ion channels, with the goal of advancing the understanding of the pathophysiology underlying the range of KCNQ2-related epilepsy disorders. The award recipient is Northwestern University, a leading private research institution, which will leverage its multidisciplinary expertise and specialized cell models, including patient-derived induced pluripotent stem cell neurons and unique mouse models, to conduct this investigation. The project began on Aug 1, 2025 and is scheduled for completion on Jul 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $874.1k | 7/30/25 |