This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $236,668 to investigate the impact of the C9ORF72 genetic mutation on the chromatin remodeling BAF complex and its role in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The awardee, Cleveland Clinic Lerner College of Medicine of Case Western Reserve...
This $1,938,189 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research into the mechanisms and toxicity of chimeric dipeptide repeat (CDPR) proteins in C9-related amyotrophic lateral sclerosis (C9ALS) and frontotemporal dementia (C9FTD). The research aims to: 1) identify the complexity, extent, and mechanism of CDPR pathology in C9ALS/FTD, 2) investigate the molecular consequences and neuronal toxicity of specific CDPR species in vitro...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $2,307,075 to The Leland Stanford Junior University to conduct innovative research aimed at defining mechanisms of neurodegenerative diseases and developing therapeutic strategies. The key research efforts include: using yeast and human genetics to identify novel...
This is a Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853). The $681,536 award to the Regents of the University of Michigan will support research to determine the molecular mechanisms underlying repeat-associated non-AUG (RAN) translation in amyotrophic lateral sclerosis (ALS) and...
This federal Project Grant award, funded by the National Institute on Aging under CFDA 93.866 (Aging Research), provides $104,164 to Emory University to explore the role of TMEM106B, a gene linked to neurodegenerative disorders. Specifically, the project aims to: 1) determine the interaction between TMEM106B and the C9ORF72 gene, which is associated with frontotemporal dementia and amyotrophic lateral sclerosis, and 2) investigate the toxicity of TMEM106B protein aggregates and their impact on...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $460,625.00 to the University of Massachusetts Medical School to investigate the roles of the deubiquitylation pathway in TDP-43 pathology related to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The 2-year project, running from June 2025 to May...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $427,625.00 to The Washington University in St. Louis, Missouri to develop novel cellular models for studying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The funded research will employ direct neuronal conversion techniques to generate...
This federal Project Grant award, with ID R61NS140724, is provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $374,349 award supports the development and optimization of a new mouse model that accurately recapitulates the full spectrum of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This model is based on the discovery that...
This Project Grant award, valued at $897,250.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant supports a comprehensive research program at St. Jude Children's Research Hospital focused on understanding the fundamental mechanisms of biomolecular condensation and its role in neurological diseases. The research aims to...