Project Grant R01NS140149

Award Date 9/18/24
Completion Date 8/31/29
Dollars Obligated $682K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Ann Arbor, MI 48109, USA
Similar Awards
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $654,423 to Emory University for a study on the mechanisms of chimeric dipeptide repeat (DPR) proteins and their role in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) associated with C9ORF72 gene expansions. The primary objectives are to: 1) identify the complexity, extent, and mechanism of chimeric DPR (cDPR) pathology in C9ALS/FTD, 2)...
This $558,182 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research to identify mechanisms of neurofilament regulation and turnover in amyotrophic lateral sclerosis (ALS). The research team at The Washington University in St. Louis will use advanced proteomic and protein kinetic analysis techniques to examine neurofilament isoforms...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $236,668 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to conduct research on the interactions between the C9ORF72 dipeptide repeat protein poly(GR) and the BAF chromatin remodeling complex. The primary goal is to elucidate how these...
This $2,307,075 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports innovative research at The Leland Stanford Junior University (Stanford University) to define novel mechanisms underlying neurodegenerative diseases and explore therapeutic strategies. Key research activities include: Using genetic screens in yeast and human cells...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,359,618 to fund research focused on understanding the role of poly-ADP-ribosylation (parylation) in C9ORF72-related amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The key objectives of this 5-year award are to: 1) comprehensively characterize the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), supports research to investigate the effects of re-expressing embryonic motor neuron selector transcription factors ISL1 and LHX3 in mouse models of amyotrophic lateral sclerosis (ALS) and in ALS patient-derived motor neurons. The key objectives are to examine how the re-expression of these factors impacts early and late ALS pathologies and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $121,554.00 to the University of California, San Diego (UCSD) to investigate the role of the KIF5A gene in amyotrophic lateral sclerosis (ALS). The research aims to: (1) examine the impact of ALS-related KIF5A mutations on the proteotoxic pathway, (2) explore the...
This Project Grant award of $443,121 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to study dysregulated protein synthesis and translation in an autism spectrum disorder (ASD) model. The project aims to leverage innovative in situ cryo-electron microscopy (cryo-EM) techniques to analyze the localization, activity, and structure of FMRP...
The $427,625 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program will support research at The Washington University in St. Louis to develop a novel cellular model for studying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research will employ direct conversion of fibroblasts into induced motor neurons...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $681,536 to conduct research aimed at deciphering the structural basis of repeat-associated non-AUG (RAN) translation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The research will use cryo-electron microscopy, biochemical and genetic approaches to determine how expanded GGGGCC repeats in the C9ORF72 gene physically interact with the ribosome to induce this non-canonical translation initiation and generate toxic dipeptide repeat proteins. The study will also investigate the role of protein factors that may bind to the translation initiation complex and promote RAN translation. This innovative research aims to provide insights into the molecular mechanisms underlying RAN translation initiation and its contribution to the development of ALS and frontotemporal dementia. The award period runs from September 18, 2024 to August 31, 2029 and is being conducted by the Regents of the University of Michigan.

Generated 4/29/25, 5:05 AM