This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $681,536 to conduct research aimed at deciphering the structural basis of repeat-associated non-AUG (RAN) translation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The research will use cryo-electron microscopy, biochemical and genetic approaches to determine how expanded GGGGCC repeats in the C9ORF72 gene physically interact with the ribosome to induce this non-canonical translation initiation and generate toxic dipeptide repeat proteins. The study will also investigate the role of protein factors that may bind to the translation initiation complex and promote RAN translation. This innovative research aims to provide insights into the molecular mechanisms underlying RAN translation initiation and its contribution to the development of ALS and frontotemporal dementia. The award period runs from September 18, 2024 to August 31, 2029 and is being conducted by the Regents of the University of Michigan.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $681.5k | 9/17/24 |