This Project Grant award of $797,157 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support research to understand the impact of post-acute sequelae of SARS-CoV-2 infection (PASC) on brain function and cognitive impairment. The research will be conducted by Yale University, leveraging their expertise in neuroscience, neuroimaging, and the established COVID Mind Study. The project aims to identify circuit-level brain...
The federal Project Grant award of $654,367.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant, awarded on January 1, 2025, supports research to investigate the neural mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 (PASC), also known as "Long COVID". The research aims to determine the relationship...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate the role of Wnt/beta-catenin signaling in maintaining blood-brain barrier integrity and reversing neurological symptoms associated with post-acute sequelae of COVID-19 (NEUROPASC). The $801,329 award, with a project period from December 1, 2024 to...
This $1,120,805 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), will support research to investigate how prior SARS-CoV-2 infection may increase the risk of vascular contributions to cognitive impairment and dementia (VCID). The research aims to: Determine how prior SARS-CoV-2 infection influences blood-brain barrier...
The National Institute on Aging (NIA) awarded a 3-year, $2,561,480 Project Grant (CFDA 93.866) to Brigham & Women's Hospital to study the post-acute sequelae of SARS-CoV-2 infection (PASC) and subsequent disease progression in individuals with mild cognitive impairment (MCI) or Alzheimer's disease (AD) and related dementias (ADRD). The project aims to: 1) understand the epidemiology of PASC in cognitively impaired individuals; 2) examine the impacts of COVID-19 and PASC on disease...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is supporting research to investigate the role of T cells in promoting post-acute memory deficits after COVID-19 infection in mice. The $107,995 award to The Washington University, which runs from July 2025 to June 2027, will fund a study to determine how pathogenic CD4+ T cells are recruited to the central nervous...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $600,000 to Rush University Medical Center to investigate the role of antibodies in the neurological effects of COVID-19. The key objectives are to: 1) elucidate the impact of inflammatory antibodies on brain cells and endothelial cells; 2) examine the trafficking and effects of inflammatory and anti-inflammatory antibodies in a chimeric human brain mouse...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $3,659,973 to the University of South Florida to investigate the molecular mechanisms underlying neurological sequelae, known as "Neuro-COVID", associated with SARS-CoV-2 (COVID-19) infection, with a focus on tau-based neurodegeneration and the impact of aging. The research aims to: 1) Assess how COVID-19 infection exacerbates age-related inflammation and tauopathy,...
This federal Project Grant award, totaling $653,192.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, supports a longitudinal study on non-invasive imaging of pathological fibrin deposition and its effects on progressive neurodegeneration in the human brain. The study, conducted by the primary awardee The General Hospital Corporation (doing business as...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Neuroscope Inc. in the amount of $1,193,370 aims to develop a computational toolset for mapping and quantifying perivascular space (PVS) morphology from MRI. The goal is to create a non-invasive, automated method to assess PVS, which is an important diagnostic feature for Alzheimer's disease and vascular dementia. The funded work will build the IT infrastructure to commercialize Neuroscope's PVS...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to investigate the mechanisms by which SARS-CoV-2 infection causes neurological damage, leading to a syndrome known as Post-Acute Sequelae of COVID-19 (PASC) or "NeuroPASC". The total award amount is $634,622.00 over the project period from December 1, 2024 to November 30, 2029.
The key objectives are to: 1) Acquire high-resolution MRI and histological datasets from post-mortem brains of NeuroPASC-positive and control individuals to confirm the hypothesized mechanisms of immune-mediated neurovascular injury and neural tissue damage, and 2) Apply advanced in-vivo MRI techniques and neuropsychological testing in NeuroPASC-positive patients and controls to link neuroimaging findings to the evolution of clinical symptoms. This research aims to establish a foundation of knowledge to inform targeted interventions for NeuroPASC and provide protocols and biomarkers to evaluate their efficacy.