This Project Grant award, valued at $654,367 and spanning from January 1, 2025 to December 31, 2029, was awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research by the Hugo W. Moser Research Institute at Kennedy Krieger, Inc. to investigate the neural mechanisms underlying fatigue associated with post-acute sequelae of SARS-CoV-2 (PASC) or "long COVID". The key objectives are to: 1) determine the relationship between blood-brain barrier permeability, neural representations of effort, and fatigue in PASC patients; 2) examine how blood-brain barrier changes influence the immediate neural response to fatiguing exertion in PASC; and 3) evaluate how blood-brain barrier permeability changes over time relate to behavioral and neural markers of fatigue in PASC. This research aims to provide a better understanding of the neurobiological mechanisms underlying fatigue in long COVID, which could inform future pharmacological interventions and rehabilitation strategies for those suffering from persistent fatigue symptoms.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $654.4k | 12/5/24 |