This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders provides $492,749 to the University of Pittsburgh to develop a non-invasive magnetic resonance imaging (MRI) technique called Ratiometric Dual Contrast (RDUAL) pH-weighted MRI. This innovative imaging approach aims to enhance the detection and delineation of the ischemic penumbra (tissue at...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $497,196 Project Grant (CFDA 93.853) to The Johns Hopkins University to develop and test new magnetic resonance spectroscopic imaging (MRSI) techniques for simultaneous mapping of both upfield and downfield proton resonances in the human brain at 3T. The key products and services to be delivered under this 4-year grant include:
Developing a new MRSI pulse sequence with improved sensitivity and excitation profiles...
This federal Project Grant award, worth $694,369, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports a multi-scale, multi-modal imaging study to examine the association between cognitive decline and changes in brain structure, function, and neuronal integrity in patients with multiple sclerosis (MS).
The primary awardee, Weill...
This $127,465 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program aims to develop a next-generation photoacoustic computed tomography device for noninvasive monitoring of cerebral metabolic rate of oxygen (CMRO2). The device will integrate technologies such as acoustic impedance-matching layers, longer-wavelength illumination, and...
This $580,654 project grant awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program aims to develop an advanced optical imaging system to quantitatively measure cerebral blood flow in patients with subarachnoid hemorrhage. The project will leverage a new interferometric diffuse optics (IDO) approach to provide highly parallel detection, time-of-flight...
The federal Project Grant award R01NS131554, "DYNAMIC CEREBROVASCULAR MORPHOLOGY CHANGES IN ACUTE ISCHEMIC STROKE", is funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $1,867,817 grant aims to investigate dynamic changes in cerebrovascular morphology after acute ischemic stroke and use cerebrovascular features to improve stroke outcome...
This Project Grant award under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, administered by the National Institute of Neurological Disorders and Stroke (NINDS), is funding the development of a highly parallelized interferometric near-infrared spectroscopy (INIRS) system for the real-time, non-invasive measurement of cerebral blood flow (CBF).
The $498,995 award to Neuralenz, Inc. aims to create an integrated platform called...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,223,140 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Chicago to test a novel biopharmaceutical agent, SANGUINATE, that aims to mitigate cerebral infarct growth in acute ischemic stroke. The goal is to evaluate SANGUINATE's ability to boost collateralization and deliver oxygen to ischemic brain tissue, potentially reducing...
This Project Grant award of $1,103,292 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program aims to develop an absolute 3D whole-brain thermometry technique using novel multinuclear MRI methods. The goal is to enable accurate detection and characterization of ischemic cerebral hyperthermia, which can accelerate stroke progression and tissue damage. The...
This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $2,156,000 to the Regents of the University of Minnesota to develop and validate innovative neuroimaging methods for quantifying oxygen availability, pH, and carbon dioxide levels in brain tissue. The goal is to establish a transformative approach for assessing neurovascular coupling and metabolic regulation in the brain, which could have significant implications for...