The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...
This $299,982 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program aims to evaluate the safety and efficacy of Unandup, LLC's novel magnetic infusion platform for accelerating alteplase-based thrombolysis to treat acute ischemic stroke. The proposed technology is designed to more rapidly convey and mix alteplase at the site of blood...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,218,750 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Trustees of the University of Pennsylvania. The funding supports research focused on developing targeted nanomedicine approaches to deliver therapeutic RNAs, such as interleukin-10 mRNA and ICAM siRNA, to the blood-brain barrier in order to restore its function and reduce inflammation...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 2-year, $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Wayne State University in Detroit, MI. The objective of this high-risk, high-reward research project is to investigate the use of remotely administered hypothermia (RAH) to the spleen as a novel neuroprotective therapy for ischemic stroke. The research aims to determine if suppressing splenic...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $490,049 to Shearit LLC to conduct research on extending the ischemic penumbra in large vessel occlusion stroke. The key objectives are to demonstrate that the polymer compound Lamiflo, when administered intravenously one hour after stroke onset, can reduce the volume of...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $231,974 Project Grant (CFDA 93.853) to Celdara Medical, LLC to develop a neuroprotective therapy for acute ischemic stroke (AIS). The project aims to demonstrate the efficacy of Celdara's lead compound, CM-EA1, in preserving neurons in the ischemic penumbra and reducing disability in AIS patients. This work will involve preclinical studies in rodent models to evaluate the therapeutic potential of CM-EA1. Celdara...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $192,500.00 to the University of Utah to conduct research on improving outcomes for acute ischemic stroke (AIS). The key objectives are to (1) determine if interventions targeting cerebral endothelial cells can improve stroke outcomes, and (2) evaluate a novel therapeutic...
This $1,079,194 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research to address the paradox of poor outcomes despite successful recanalization in stroke patients. The key objectives are to: 1) create a longitudinal clinical and imaging dataset to evaluate the role of final infarct volume on outcomes; 2) propose,...
This $458,005 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program supports a research project led by Dr. James Giles at Yale University. The project aims to analyze the transcriptomics (gene expression profiles) of blood and thrombus (clot) samples from patients with acute ischemic stroke caused by large vessel occlusion. The goal...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $853,135 to Dignity Health's St. Joseph's Hospital and Medical Center in Phoenix, AZ to conduct research on the role of the complement C3A receptor in exacerbating brain injury after stroke. The key objectives are to: 1) demonstrate that genetic inhibition of the...