This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on investigating the impact of SARS-CoV-2 infection on the cerebrovascular system and its potential role as a risk factor for vascular contributions to cognitive impairment and dementia (VCID). The $1,120,805 award, granted to the University of Illinois, will examine three key...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $654,367 to the Hugo W. Moser Research Institute at Kennedy Krieger, Inc. in Baltimore, MD. The award supports research to investigate the neural mechanisms of fatigue in individuals with post-acute sequelae of SARS-CoV-2 (PASC), also known as "long COVID." The...
This $634,622 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to investigate the mechanisms by which SARS-CoV-2 infection leads to long-term neurological symptoms, known as neurological post-acute sequelae of SARS-CoV-2 (NeuroPASC). The 5-year project will utilize advanced in-vivo and ex-vivo MRI techniques, histological...
This Project Grant award from the National Institutes of Health (CFDA 93.310 Trans-NIH Research Support program) provides $600,000 to Rush University Medical Center to investigate the role of antibodies in the neurological effects of COVID-19, known as "neurocovid-19." The central hypothesis is that inflammatory IgG antibodies associated with SARS-CoV-2 infection can trigger activation and damage to brain cells and endothelial cells, disrupting brain homeostasis. The research aims...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,218,750 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Trustees of the University of Pennsylvania. The funding supports research focused on developing targeted nanomedicine approaches to deliver therapeutic RNAs, such as interleukin-10 mRNA and ICAM siRNA, to the blood-brain barrier in order to restore its function and reduce inflammation...
This Project Grant award of $506,052 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program will support research to investigate the potential neuropathological interactions between COVID-19 infection and the progression of Lewy body pathology and dementia. The research aims to determine if virus-induced genotoxic stress can accelerate the development of...
This $230,580 Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the mechanisms underlying brain-immune interactions at the blood-brain barrier. The overarching goal is to generate novel targets for immunotherapy in neuroinflammatory conditions. The research approach combines genetic manipulation of the brain...
This federal Project Grant award of $291,020.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, will fund research at the University of Colorado-Denver to investigate the role of Wnt signaling effectors on the neuron-glia switch and oligodendrocyte progenitor cell (OPC) specification during development and after spinal cord injury. The research aims to determine how Axin1...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, provides $566,089 to The Ohio State University to conduct research under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The research aims to understand the causal relationship between acute pneumonia and reduced neurological recovery following spinal cord injury (SCI). Specifically, the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,174,984 to the University of South Florida to investigate the molecular mechanisms underlying neurological sequelae, known as "Neuro-COVID," associated with SARS-CoV-2 (COVID-19) infection, particularly in the context of aging and pre-existing tauopathy. The research aims to characterize the neuropathology and cognitive deficits in mouse models, identify key molecular...