Project Grant R01NS134958
- The National Institute of Mental Health (NIMH) has awarded a $1,388,925 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Regents of the University of California, San Francisco (UCSF) to conduct research on the role of vascular mural cells in the development of the blood-brain barrier. The key objectives of this 3-year grant are to: 1) Construct a spatiotemporal atlas of brain mural cells during development using single-cell RNA sequencing and tissue-based...
- This Project Grant award of $5,949,022, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to identify novel therapeutic targets for treating cerebral amyloid angiopathy (CAA) and vascular contributions to cognitive impairment and dementia (VCID). The research, led by the Jackson Laboratory with sub-awards to Emory University, Rush...
- This three-year, $4.84 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at The Johns Hopkins University to investigate the neurological effects and cumulative risk of neurodegenerative disease from exposure to metal mixtures. Specifically, the researchers will examine the biological mechanisms by which exposure to mixtures of lead, arsenic, cadmium, and chromium during adulthood and early development cause...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides $776,503 to The General Hospital Corporation (Massachusetts General Hospital) to investigate the role of perivascular inflammation and vascular remodeling in cerebral small vessel diseases (CSVD), which can lead to intracerebral hemorrhage. The project will leverage autopsy cases and mouse...
- Federal Project Grant Award Summary The University of California, San Francisco (UCSF) received a $1.476 million Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) for the period August 1, 2025 through July 31, 2028. The award supports research to develop therapeutic interventions for preterm white matter injury (PWMI), the most common type of brain injury in premature infants. The research delivers a...
- This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $2,357,335 to study neuronal dysfunction in Down syndrome (DS) and its link to Alzheimer's disease (AD). The key products and services delivered under this award include: Utilizing induced pluripotent stem cell (iPSC)-derived cortical organoids and assembloids to examine the cellular, transcriptomic, and motility-related...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $110,577 to The Regents of the University of Colorado (University of Colorado-Denver) on July 23, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award funds research investigating the mechanisms and impact of amyloid-beta (Aβ) mediated disruption of synaptic nanoarchitecture, with a completion...
- This Project Grant award of $248,999.00 from the National Eye Institute's Vision Research program (CFDA 93.867) supports research at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to investigate how neuronal synaptic activity and neurotransmitters influence retinal angiogenesis and the development of the blood-retinal barrier. The research aims to elucidate the role of glutamate release on deep retinal vascular plexus formation and barrier maturation, and...
- This $438,342 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to study the fundamental mechanisms by which ubiquitin ligases recognize and ubiquitinate substrates within protein complexes. The research focuses on understanding the role of the anaphase-promoting complex (APC) in regulating the composition of neuronal...
- Federal Project Grant Award Summary The University of Connecticut Health Center (UCHC) received a $680,941 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective July 7, 2025, with a completion date of June 30, 2030. This research project investigates the unique role of ASPM (assembly factor for spindle microtubules) in the development of...
THE ROLE OF COPPER IN CHOROID PLEXUS - PROJECT SUMMARY COPPER (CU) HAS A CRITICAL AND MULTIFACETED ROLE IN THE DEVELOPMENT AND FUNCTION OF MAMMALIAN BRAIN. CU MISBALANCE IS OBSERVED IN MANY DISORDERS AFFECTING THE CENTRAL NERVOUS SYSTEM: MENKES DISEASE, WILSON DISEASE, ALZHEIMER'S AND PARKINSON'S DISEASES, MULTIPLE SCLEROSIS, AND OTHERS. WITH THE EXCEPTION OF MENKES DISEASE, FOR MOST OF THESE DISORDERS THE ORIGIN OF CU MISBALANCE IN THE BRAIN IS NOT WELL UNDERSTOOD, AND WHETHER CU FLUXES IN AND OUT OF THE BRAIN ARE COMPROMISED REMAINS UNKNOWN. THE INFORMATION ABOUT CU ENTRY INTO THE HEALTHY BRAIN IS ALSO VERY LIMITED. THE PROPOSED PROGRAM OF STUDIES WILL CLARIFY THE MECHANISM REGULATING CU TRANSFER THROUGH CHOROID PLEXUS (CHPL), AN IMPORTANT SECRETORY TISSUE, WHICH PRODUCES CEREBROSPINAL FLUID AND FORMS THE BRAIN-CEREBROSPINAL FLUID BARRIER. STUDIES UNDER SPECIFIC AIM 1 WILL DETERMINE THE ROLE OF CHPL IN CU ENTRY INTO THE PERINATAL BRAIN. THE ABUNDANCE, LOCALIZATION, AND FUNCTIONAL INTERACTIONS BETWEEN THE CU TRANSPORTERS ATP7A, ATP7B, AND SLC31A1(CTR1) AS WELL AS ENDOGENOUS CU CHELATORS, METALLOTHIONEINS, WILL BE CHARACTERIZED AT DIFFERENT TIME POINTS OF HEALTHY BRAIN MATURATION, AND THESE CHARACTERISTICS WILL BE COMPARED FOR CONTROL AND ATP7B-/- MICE, AN ANIMAL MODEL OF WILSON DISEASE. TARGETED DELETION OF CTR1 AND ATP7A IN MOUSE CHPL EPITHELIUM WILL BE USED TO MEASURE CONTRIBUTION OF CHPL TO CU TRANSPORT INTO THE PERINATAL BRAIN. SPECIFIC AIM 2 WILL IDENTIFY THE MECHANISTIC LINK BETWEEN CU HOMEOSTASIS IN CHPL, ORGANIZATION OF CHPL CYTOSKELETON AND THE DEVELOPMENT OF CILIA; THIS WILL BE ACHIEVED USING TRANSMISSION ELECTRON MICROSCOPY, IMMUNOCYTOCHEMISTRY, AND PROTEOMICS. THE IMPACT OF CU MISBALANCE IN ATP7B-/- CHOROID PLEXUS ON EXPRESSION AND ACTIVITY OF PEPTIDYL-A-AMIDATING MONO-OXYGENASE (PAM), A CU-DEPENDENT ENZYME ASSOCIATED WITH CILIA DEVELOPMENT WILL BE EXAMINED. HOW CHANGES IN CU HOMEOSTASIS IN CHPL MODIFY THE CHPL SECRETOME WILL BE DETERMINED BY EMPLOYING ISLET METHODOLOGY (IN SITU SECRETORY PROTEIN LABELING VIA ER- ANCHORED TURBOID) AND MASS-SPECTROMETRY.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $463.3k | 8/5/25 | ||
| Not listed | $502.3k | 7/29/24 |