This federal Project Grant award in the amount of $684,451 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders supports a comprehensive research effort to advance understanding and treatment of Parkinson's disease. The project aims to: Identify Parkinson's disease progression subtypes through integrative analysis of longitudinal clinical, transcriptomic, and neuroimaging data...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $173,140 to The Regents of the University of California, San Francisco (UCSF) to investigate the role of neural activity in the degeneration of midbrain dopamine neurons associated with Parkinson's disease. The project aims to develop novel mouse models to chronically...
This $475,475 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts. The goal of the award is to evaluate a small molecule inhibitor of the USP30 enzyme as a potential neuroprotective therapy for Parkinson's disease. The research will assess...
This $2,208,982 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research to investigate the role of interleukin-13 (IL-13) and its receptor IL-13Rα1 in the development of Parkinson's disease (PD). The researchers at the San Diego Biomedical Research Institute aim to determine the molecular and cellular mechanisms by which IL-13 and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research to explore the role of neuromelanin accumulation in dopamine neurons and its influence on Parkinson's disease pathogenesis. The $616,200 award to the Oklahoma Medical Research Foundation (OMRF) will leverage expertise across three established labs to study the anatomical,...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $350,036 to the University of Alabama at Birmingham to conduct research aimed at understanding the cellular and molecular changes in a specific subpopulation of neurons that are associated with the development of levodopa-induced dyskinesia (LID), a debilitating side effect of...
This $1,002,148 federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the role of autophagy, a cellular mechanism for clearing damaged organelles and harmful materials, in neurological diseases like Parkinson's, Alzheimer's, and ALS. The research aims to determine how the regulation of...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $646,104 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the San Diego Biomedical Research Institute, a non-profit research organization. The grant supports research to investigate how neuroinflammation mediated by the interleukin-13 receptor signaling pathway may contribute to the selective loss of dopaminergic neurons in Parkinson's disease. The...
This $682,698 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to investigate the mechanisms of manganese-induced neurotoxicity mediated through the leucine-rich repeat kinase 2 (LRRK2) in microglia. The project aims to elucidate how manganese exposure increases LRRK2 expression and kinase activity, leading to impairment of mitochondrial function, lysosomal defects, and...
The Research Foundation for the State University of New York (RF SUNY) received a $158,379 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The funding will support research to understand how the protein alpha-synuclein (α-syn) contributes to mitochondrial dysfunction in Parkinson's disease (PD). The project aims to isolate the...