This $688,904 Project Grant award from the National Institute of Environmental Health Sciences (CFDA 93.113 Environmental Health) supports research on the gene-environment interactions linking developmental manganese (Mn) exposure and the increased risk of attention-deficit/hyperactivity disorder (ADHD). The five-year study, conducted by Vanderbilt University Medical Center (VUMC) and involving sub-awards to Purdue University and Vanderbilt University, aims to: 1) Determine the role of sex and...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program will provide $441,529 to the University of Georgia Research Foundation, Inc. to investigate the role of epitranscriptomic mechanisms, specifically the m6A RNA modification and associated regulatory proteins, in modulating astrocyte function and neuroimmune homeostasis during manganese neurotoxicity. The key objectives are to: 1) elucidate if...
This federal Project Grant award of $499,286.59, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to elucidate the relationship between oxidative stress and the LRRK2 protein in the pathogenesis of Parkinson's disease. The 4-year project, with an award period of August 23, 2024 to July 31, 2028, focuses on three broad aims: 1) examining...
This federal Project Grant award of $822,643.00, awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund a research project to investigate how chronic exposure to common environmental neurotoxicants like lead, cadmium, and arsenic impact brain aging and the risk of late-onset Alzheimer's disease (LOAD). The researchers at Boston University Medical Campus, the prime awardee, will use innovative mouse models developed by the Model-AD Consortium to study...
This federal Project Grant award, with a total funding amount of $585,531, was provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program. The primary recipient, Dignity Health doing business as St. Joseph's Hospital and Medical Center, is conducting the "South African Manganese Environmental Neurotoxic Effects Research (SMELTER)" project. The key products and services delivered under this grant include assembling...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, supports research to examine the role of noradrenergic signaling and the locus coeruleus in mediating the effects of developmental lead exposure on stress responses. The $400,847 award to Louisiana State University, with a project period from May 2025 to May 2027, aims to delineate how lead-induced disruptions in noradrenergic signaling...
This $704,695 federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to determine the dose-response relationship between exposure to aerosolized brevetoxins from harmful algal blooms and neurological symptoms in humans. The primary awardee, The Roskamp Institute, Inc., a non-profit biotechnology research organization in Sarasota, Florida, will conduct this research project from...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program is for $728,408 and aims to biologically validate novel genetic variants that may confer susceptibility to pesticide-induced Parkinson's disease. The award supports two key efforts: Evaluating the effects of upregulating and downregulating candidate genes on oxidative stress markers in human dopaminergic neurons derived from induced...
This $227,205 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the effects of the Parkinson's disease-associated protein LRRK2 on lysosomal function and inflammatory activity in microglia. The primary objectives are to: 1) examine how LRRK2 and the Parkinson's disease risk gene GBA1 interact to regulate lysosomal...
This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on exploring the role of neuromelanin accumulation in dopamine neurons and its impact on Parkinson's disease. The $616,200 award to the Oklahoma Medical Research Foundation (OMRF) will support experiments to investigate how progressive neuromelanin buildup in mouse...