The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $478,417 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of California, Davis. This 5-year grant, effective from September 1, 2024 to August 31, 2029, will support the development of a new multi-functional extracellular vesicle-based nanotherapeutic for the treatment of multiple sclerosis (MS). The key objectives are to engineer...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $667,644 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to the Icahn School of Medicine at Mount Sinai. This 5-year grant, effective August 1, 2024, will support research to further the understanding of cortical lesion formation, repair, and their relation to disability in early multiple sclerosis (MS). The research aims to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $305,000 to Saint Louis University to conduct research on stem-like T cells and their role in multiple sclerosis (MS). The key objectives are to: Rigorously test the hypothesis that continuing stemness and differentiation of CD4+ T stem cells leads to functional and transcriptomic diversification under autoimmune...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding research to investigate the role of endosomal Toll-like receptors (TLRs) in remyelination and demyelinating diseases. The $109,671 award, spanning July 2024 to June 2026, will support the University of Massachusetts Medical School's research to understand how aberrant...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program provides $647,782 to the San Diego Biomedical Research Institute to evaluate the therapeutic potential of hypoxia mimetics in treating inflammatory demyelinating diseases like multiple sclerosis (MS). The key research activities include: 1) Defining an optimal treatment protocol...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research focused on understanding the role of cellular prion protein (PrPc) and its receptor LRP1/NMDA-R in regulating neuroinflammation and disease progression in neurodegenerative disorders. The $563,313 award to the University of California, San Diego (UCSD) aims...
This $992,377 Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) supports research at the University of Colorado-Denver to investigate the mechanisms of IgG antibody-mediated neuronal cytotoxicity in multiple sclerosis. The 3-year research project aims to advance understanding of the immunological processes underlying neurological damage in multiple sclerosis patients. The University of Colorado-Denver, a major public...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the NIH, provides $742,352 to New York University School of Medicine to conduct the "Childhood Adversity Research Effort in Multiple Sclerosis (CARE.IN.MS)" study. The goal is to collaboratively develop and execute a comprehensive, culturally-informed multicenter study examining the relationship between childhood adversity and health outcomes for individuals with multiple...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $426,938 to Virginia Commonwealth University to conduct research on the role of the GLT-1/EAAT2 signaling pathway in oligodendrocytes and its potential for promoting myelin repair in multiple sclerosis (MS). The award period runs from July 9, 2024 to June 30, 2026. The...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a computational model for evaluating cognitive impairment in multiple sclerosis (MS). The goal is to provide a psychometrically valid and biologically informed update to the existing framework for characterizing cognition in MS. The $654,287 award, with a...