This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research to evaluate the therapeutic potential of hypoxia mimetics in treating inflammatory demyelinating disease, particularly multiple sclerosis (MS). The $1,949,990 award, running from August 1, 2024 to June 30, 2029, will support research to: 1) define an optimal...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $706,959 to the University of California, Davis (UC Davis) to conduct research on the molecular signaling mechanisms that regulate the growth, stabilization, and functional maturation of dendritic spines and their associated synapses. The research aims to elucidate the role...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $4,164,187.00 to The Regents of the University of California, San Francisco to develop an approach for discovering and characterizing autoantibodies directed to cell surface antigens that may be pathogenic in autoimmune neuroinflammatory diseases. The award will support the...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...
This Project Grant award, valued at $352,073.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research focused on developing a therapeutic to address demyelinating neuropathies, a class of neurological disorders characterized by impaired myelin formation. Specifically, the research will investigate the use of an...
The University of California, Davis (UC Davis) received a $1,414,340 Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to develop and deploy new molecular technologies that will enable the sub-cellular tagging and enrichment of proteins in activated subgroups of neurons in the brain. The goal is to link protein expression to neural function at a large and unbiased scale, which is not currently possible with existing...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the "Development of a Nanobody Tool Kit to Study Connexin Channels" at the University of California, Davis. The $201,250 award, spanning September 1, 2024 to August 31, 2026, will fund research to investigate the 21 different connexin isoforms in humans that play crucial roles in intercellular communication...
This federal Project Grant award of $997,060 from the Department of Defense's Military Medical Research and Development program (CFDA 12.420) supports research at the University of California, San Francisco (UCSF) to develop a new understanding of selective neuron vulnerability and neuroprotection in progressive multiple sclerosis. The award has a performance period from September 15, 2024 to September 14, 2027. As a leading academic medical center and research institution, UCSF will leverage...
This $4,693,249 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program will fund research to define the molecular pathways driving vascular cognitive impairment and dementia (VCID). The goal is to develop a VCID Center with Outreach (CWOW) that will advance the mechanistic understanding of how cerebral small vessel disease leads to...
The University of California, San Diego (UCSD) has been awarded a $434,500 Project Grant by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This 2-year grant will support research to determine the signaling pathways activated by prion protein in human induced pluripotent stem cell (iPSC)-derived neurons. The research aims to establish the sequence of intracellular...