Project Grant R01MH144672
- The National Institute of Mental Health awarded the President and Fellows of Harvard College, through its Harvard T.H. Chan School of Public Health division, $418,000 on August 10, 2026, to identify epigenetic biomarkers that predict the risk and progression of depression among young adolescents under the Mental Health Research Grants program (CFDA 93.242). The recipient will investigate how DNA methylation and microRNA expression mediate the effects of early life stress on adolescent...
- The National Institute of Mental Health awarded $1.579 million to the Research Foundation For Mental Hygiene, Inc., operating as the New York State Psychiatric Institute, on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to fund basic neuroscience research into the circuit mechanisms by which early-life adversity produces sustained reward deficits. The research examines how childhood trauma—including abuse, neglect, and chronic stress—alters neural circuits governing...
- The National Institute of Mental Health awarded the Research Foundation For Mental Hygiene, Inc. $450,175 on July 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of hippocampal dopamine in early life adversity effects on fear generalization. The award funds basic neuroscience research examining how dopamine and norepinephrine release from locus coeruleus projections to the ventral dentate gyrus of the hippocampus dynamically control and...
- The National Institute of Mental Health awarded New York University $1.694 million on June 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct bioinformatic and experimental research on long non-coding RNAs (lncRNAs) in stress response and psychiatric disorder resilience. The research integrates genetic, transcriptional, and epigenetic datasets to identify lncRNAs mediating stress susceptibility and resilience in the brain. The project involves two primary aims:...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $839,815 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a clinical and translational research project investigating neuroimmune mechanisms of depression and anhedonia. The project tests the hypothesis that heightened peripheral immune function and increased blood-brain barrier permeability contribute to major depressive disorder and anhedonia severity. Work is...
- The National Institute of Mental Health awarded The Trustees of Columbia University in the City of New York $534,191 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop robust fine-mapping tools for genetic discovery in neuropsychiatric traits using deep phenotype data from diverse populations. The project addresses the challenge of understanding genetic causes of complex neuropsychiatric conditions including autism spectrum disorders, bipolar disorder, and...
- The National Institute of Mental Health awarded The Regents of the University of Colorado $730,338 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to identify genetically distinguishable subgroups within major depressive disorder. The recipient will conduct genome-wide association studies (GWAS) of major depressive disorder subtypes, including sex-stratified, atypical, postpartum, and severe forms, leveraging the Psychiatric Genomics Consortium Major Depressive...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $169,701 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct multiomic and spatial profiling of hippocampal development and subfield specification. The research deploys single-nucleus RNA sequencing, single-nucleus ATAC sequencing, and spatial sequencing on human fetal hippocampal and neocortical tissue (gestational weeks 16–24) and human induced pluripotent stem...
- The National Institute of Mental Health awarded $466,175 to Massachusetts General Hospital on August 11, 2026, under the Mental Health Research Grants program (CFDA 93.242) to map neuroimmune circuitry implicated in major depressive disorder and treatment-resistant depression. The recipient will conduct multimodal neuroimaging and anatomical research to elucidate circuits connecting limbic regions with the nucleus tractus solitarii in the brainstem, a neural pathway through which inflammatory...
- The National Institute of Mental Health awarded The Johns Hopkins University $384,245 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop DNA probes and modified extracellular vesicles as therapeutic tools to reverse stress-induced epigenetic changes in the brain. The project addresses the role of chronic stress and cortisol exposure in causing epigenetic modifications that disrupt genes critical for brain function and neurodevelopment, contributing to...
The National Institute of Mental Health awarded Research Foundation For Mental Hygiene, Inc. (operating through its New York State Psychiatric Institute division) $818,498 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how individual differences in hippocampal gene expression modify susceptibility and resilience to depression following early adversity in adolescents. The research will determine whether innate variation in expression of adversity-, resilience-, and depression-related genetic pathways in the hippocampus increases or decreases risk for depression after early adverse experiences. The team will first identify relevant hippocampal gene networks using causal mouse models and postmortem human brains, then apply innovative expression-based polygenic scores to data from the Adolescent Brain Cognitive Development Study (a longitudinal cohort of 11,700 adolescents) to assess whether individual differences in these genetic pathways modify depression risk. The research team integrates expertise in basic neuroscience, clinical and developmental psychology, translational epidemiology, statistical genomics, and biostatistics to examine the intersection of neuroscience, genomics, and epidemiology in depression pathophysiology. Performance occurs in New York, New York, with a performance period from August 1, 2026, through April 30, 2031. This is a Project Grant (R01 mechanism) classified as assistance funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $818.5k | 7/22/26 |