Project Grant R01MH144491
- This federal Project Grant award of $470,996 from the National Institute of Mental Health (NIMH), under the CFDA program "Mental Health Research Grants", supports research on the neural basis of human working memory. The research aims to gain a better understanding of the neurological mechanisms underlying working memory, which is impaired in various mental illnesses and neurological conditions. Key activities include obtaining neurophysiological recordings from human patients with...
- The National Institute of Mental Health awarded Scripps Research Institute $878,601 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support structural remodeling of neural circuits via multisynaptic boutons. The research uses three-dimensional electron microscopy at nanometer resolution to reconstruct neuronal connectomes, individual synapses, and glia in the mammalian brain. The work combines 3D-EM with chemogenetic techniques for labeling cellular ensembles...
- The National Institute of Mental Health awarded Trustees of Boston University $449,625 on March 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate molecular, cellular, and circuit-level mechanisms of working memory maintenance. The recipient will conduct research across multiple biological scales to understand how working memory—the transient maintenance of past events in the brain for comparison with ongoing experiences—functions normally and becomes impaired...
- The National Institute of Neurological Disorders and Stroke awarded Cedars-Sinai Medical Center $190,321 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the neurophysiology of cognitive control and its development using single unit intracranial recordings in pediatric patients with epilepsy. The research examines how adaptive behavioral control develops during childhood and is instantiated by...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $701,763 on April 24, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of the ventral CA1 hippocampal subregion in valence-associated social memories and emotional memory processing. The five-year project, which runs through January 31, 2031, will uncover the neural circuits mediating positive and negative social memories, identify hippocampal cell types supporting...
- The National Institute of Mental Health awarded New York University $110,228 on October 6, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate hippocampal-neocortical coupling in memory consolidation. The funded research examines how hippocampal sharp-wave ripples facilitate communication between the hippocampus and neocortex during non-rapid eye movement sleep and support long-term memory consolidation. The project includes three parallel studies: analysis of...
- Cedars-Sinai Medical Center was awarded a three-year, $934,850 Project Grant from the National Science Foundation Division of Behavioral and Cognitive Sciences under the Social, Behavioral, and Economic Sciences federal grant program (CFDA 47.075). The grant will support research using single-neuron recordings in the human brain to test theories of error monitoring and gain mechanistic insights into how the medial prefrontal cortex enables performance monitoring. Key products include testing...
- The National Institute of Mental Health awarded the Research Foundation For Mental Hygiene, Inc. (Nathan S Kline Institute) $745,840 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to define optimal timing and cognitive states for memory consolidation during wakefulness and test causal mechanisms for targeted memory modulation. The research determines when memory consolidation maximally occurs during post-learning wakefulness by systematically decomposing awake...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a Project Grant of $150,104 to The Regents of the University of California, San Francisco under the Mental Health Research Grants program (CFDA 93.242) to conduct basic neuroscience research investigating the relationship between myelin plasticity and long-term memory formation. The research project, active from March 1, 2026 through October 31, 2028, will employ an active avoidance learning paradigm in mice to...
- The National Institute of Mental Health awarded Drexel University $412,550 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a closed-loop functional magnetic resonance imaging study testing whether neural reactivation causally promotes long-term memory retention. The project establishes proof-of-principle for a real-time neuroimaging approach—closed-loop neural reinforcement—to manipulate distributed neural activity patterns during memory consolidation....
The National Institute of Mental Health awarded Cedars-Sinai Medical Center $742,102 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the neural mechanisms of human working memory through in-vivo single-neuron recordings in patients undergoing treatment for drug-resistant epilepsy. The research deciphers the role of delay-period neural activity in working memory maintenance by recording simultaneously from multiple brain areas. The work characterizes the neural code supporting maintenance of visual, semantic, and control signals; identifies how working memory avoids interference from perceptual distractors; and examines the causal role of delay-period activity through electrical stimulation. Deliverables include a novel computational framework for determining what aspects of memoranda are encoded by individual neurons and identification of which cells and brain areas support specific working memory functions, including human-specific language-based representations. The award funds research conducted at Cedars-Sinai Medical Center in West Hollywood, California, with a period of performance through June 30, 2031. The assistance type is a Project Grant, the standard NIH research grant mechanism supporting specified project periods not in excess of five years.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $742.1k | 9/1/26 |